Critical Illness Myopathy and Trajectory of Recovery in AKI Requiring CRRT

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-11-29

Study Completion Date

2024-12-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine whether patients with acute kidney injury requiring renal replacement therapy have a higher incidence of muscle wasting than controls and whether the course of recovery is longer compared to controls.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Skeletal Muscle Wasting and Renal Dysfunction After Critical Illness Trauma - Outcomes Study

NCT03736005

Critical Illness Acute Kidney Injury Muscle Loss +3 more

COMPLETED

Roles of Uremic Toxins in Uremic Sacropenia

NCT03060590

Sarcopenia

COMPLETED

Determinants of Muscle Strength in Chronic Kidney Disease

NCT02806089

Chronic Kidney Disease

COMPLETED NA

Essential Nutrients in Critically Ill Patients With Severe AKI Treated With and Without CRRT

NCT02470520

Acute Kidney Failure

COMPLETED

Assessment of Kidney Function and Osteomuscular Status After Critical Care

NCT04980092

Critical Illness Kidney Injury Muscle Loss +1 more

SUSPENDED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Acute kidney injury (AKI), the abrupt loss of kidney function, is a common complication that affects more than half of all intensive care unit (ICU) admissions, and it is associated with substantially higher rates of morbidity and mortality in both the short- and the long-term. This is especially true in patients with AKI requiring renal replacement therapy (AKI-RRT), also known as dialysis. An understudied mechanism by which AKI-RRT may contribute to poor clinical outcomes, both in the hospital and after discharge, is through its impact on muscle mass and muscle function. AKI of any severity is known to alter tissue utilization of amino acids, and preliminary data suggest that RRT in the ICU may exacerbate muscle dysfunction through the removal of large quantities of amino acids from the patient's plasma. This study will determine whether patients with AKI-RRT have greater lean muscle loss over 1 week than historical critically ill controls, whether patients with AKI-RRT have diminished recovery of muscle mass and function at 1-3 months following discharge compared to controls, and whether changes in plasma levels of amino acids during hospitalization correlate with loss of muscle function or lack of recovery.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Kidney Injury Critical Illness Myopathy Dialysis; Complications

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

AKI-RRT

Adults admitted to the ICU with AKI requiring CRRT with study enrollment within 48 hours of CRRT initiation.