Relation Between Acute Kidney Injury and Mineral Bone Disease
NCT ID: NCT05548725
Last Updated: 2022-09-21
Study Results
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Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2022-09-25
2023-10-31
Brief Summary
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Detailed Description
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Numerous studies have evaluated the prevalence and importance of mineral and bone disorders among patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, little is known about dysregulated mineral and bone metabolism in acute kidney injury (AKI) \[ Acute kidney injury is the new consensus term for acute renal failure It refers to a clinical syndrome characterised by a rapid (hours to days) decrease in renal excretory function, with the accumulation of products of nitrogen metabolism such as creatinine and urea and other clinically unmeasured waste products. Other common clinical and laboratory manifestations include decreased urine output (not always present), accumulation of metabolic acids, and increased potassium and phosphate concentrations. The term acute kidney injury has replaced acute renal failure to emphasise that a continuum of kidney injury exists that begins long before sufficient loss of excretory kidney function can be measured with standard laboratory tests. The term also suggests a continuum of prognosis, with increasing mortality associated with even small rises in serum creatinine, and additional increases in mortality as creatinine concentration rises. The incidence of acute kidney injury (AKI) is increasing among hospitalized patients . Treating the condition consumes significant amounts of resources even after hospital discharge
. Although AKI was once considered a reversible condition, mounting evidence has indicated that AKI may have a negative impact upon subsequent renal function and long-term prognosis, even if kidney
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Reguired field
Investigations to know relationship between acute kidney injury and mineral bone disease
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Non cardiac
* Active malignancy
* Acute or chronic liver disease
* Acute poisoning
* Covid
18 Years
65 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Asmaa Ahmed Mohamed Abd Elraheem
Director
Central Contacts
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References
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Agar A, Gulabi D, Sahin A, Gunes O, Hancerli CO, Kilic B, Erturk C. Acute kidney injury after hip fracture surgery in patients over 80 years of age. Arch Orthop Trauma Surg. 2022 Sep;142(9):2245-2252. doi: 10.1007/s00402-021-03969-y. Epub 2021 May 31.
Koizumi M, Komaba H, Fukagawa M. Parathyroid function in chronic kidney disease: role of FGF23-Klotho axis. Contrib Nephrol. 2013;180:110-23. doi: 10.1159/000346791. Epub 2013 May 3.
Wesseling-Perry K, Salusky IB. Phosphate binders, vitamin D and calcimimetics in the management of chronic kidney disease-mineral bone disorders (CKD-MBD) in children. Pediatr Nephrol. 2013 Apr;28(4):617-25. doi: 10.1007/s00467-012-2381-8. Epub 2013 Feb 5.
Other Identifiers
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Relation between AKI and BMD
Identifier Type: -
Identifier Source: org_study_id
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