Early Renal Replacement Therapy in COVID 19 Patients With AKI Does it Improve the Outcome?

NCT ID: NCT05274685

Last Updated: 2022-03-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-06-01

Study Completion Date

2022-01-01

Brief Summary

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patients will be divided into two equal groups, each group including 50 adult patients with a confirmed diagnosis of covid, patients with acute kidney injury, the first group will be treated with early hemodialysis, second group will be conservative until there is an urgent need for dialysis

Detailed Description

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Conditions

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Multi Organ Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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covid positive with acute kidney injury receiving early renal replacement

Group Type EXPERIMENTAL

haemodialysis

Intervention Type PROCEDURE

continuous venovenous hemodiafiltration (CVVHDF) at a prescribed dose of 30-35 mL/kg/h of effluent and with regional citrate anticoagulation

covid positive with acute kidney injury under conservative management

Group Type EXPERIMENTAL

haemodialysis

Intervention Type PROCEDURE

continuous venovenous hemodiafiltration (CVVHDF) at a prescribed dose of 30-35 mL/kg/h of effluent and with regional citrate anticoagulation

Interventions

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haemodialysis

continuous venovenous hemodiafiltration (CVVHDF) at a prescribed dose of 30-35 mL/kg/h of effluent and with regional citrate anticoagulation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* adult patients (≥18 years old) with confirmed severe acute respiratory syndrome coronavirus 2 infections admitted to the ICU.

Exclusion Criteria

* •Malignancy.

* Immuno-deficiency diseases.
* Chronic diabetic, cardiac and hypertensive patients
* autoimmune diseases.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Islam Mokhtar Ahmed

lecturer of anesthesia and intensive care

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculty of Medicine, Sohag University

Sohag, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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soh-Med-22-2-24

Identifier Type: -

Identifier Source: org_study_id

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