Biology of Young Lung Cancer Study: The YOUNG LUNG Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-01

Study Completion Date

2027-08-01

Brief Summary

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The purpose of this research study is to learn more about lung cancer (NSCLC or SCLC) diagnosed in adults at ages 45 or younger.

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Detailed Description

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This research study looks to enroll as many people diagnosed with lung cancer at 45 years old or younger in order to:

* Better understand causes of lung cancer in individuals 45 years old and younger, which is a rare disease
* Better estimate lung cancer risks and potential risk factors for lung cancer in individuals 45 years old and younger
* Examine tumor (somatic) or normal (germline) genetic changes that may be shared among young lung cancer patients
* Improve opportunities for screening and treatment of lung cancer in individuals 45 years old and younger

Study procedures will include:

* Collecting information from participants' medical record and two (2) short questionnaires
* Collecting blood and/or saliva samples
* Collecting tumor tissue samples (optional)

It is expected that about 500 people will take part in this research study. Participants will be in this study until it closes or the participant withdraws consent.

Conditions

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Non Small Cell Lung Cancer Small Cell Lung Carcinoma NUT Carcinoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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Data/Biospecimen Collection

Tumor and saliva specimens from participants with non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC) diagnosed at age 45 or younger

Data and Specimen Collection

Intervention Type GENETIC

* Provide research team access to relevant medical records
* Answer two (2) short questionnaires at time of consent
* Provide up to 5 tubes (37 ml) of blood at or near the time of consent, and/or saliva sample
* Consider consenting to other optional parts of the research such as:

* Providing additional blood or tissue samples in the future (optional)
* Providing permission for obtainment of stored tissue specimens from lung cancer surgeries or biopsies from the pathology departments where they have been stored (optional)

Interventions

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Data and Specimen Collection

* Provide research team access to relevant medical records
* Answer two (2) short questionnaires at time of consent
* Provide up to 5 tubes (37 ml) of blood at or near the time of consent, and/or saliva sample
* Consider consenting to other optional parts of the research such as:

* Providing additional blood or tissue samples in the future (optional)
* Providing permission for obtainment of stored tissue specimens from lung cancer surgeries or biopsies from the pathology departments where they have been stored (optional)

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Age 45 and under at lung cancer diagnosis
* Pathologically confirmed bronchogenic lung carcinoma (NSCLC or SCLC of any stage) at any treatment time point
* Provision of written informed consent
* Willingness to undergo no more than two (2) peripheral blood draws in a four (4) week period, with no more than 50 ml peripheral blood collected over eight (8) weeks
* Individuals under age 18 are eligible for study if they meet defined criteria; in addition, consent for participation must be given by a legal guardian or parent

Exclusion Criteria

* Individuals who decline to sign consent
* Individuals who are unable to give consent or assent and are without a designated healthcare proxy
* Compromise of patient diagnosis or staging if tissue is used for research

Minimum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No