Blood Sample Collection in Subjects Participating in a Lung Cancer Screening Program

NCT ID: NCT03628638

Last Updated: 2021-02-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1718 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-04-06

Study Completion Date

2021-01-31

Brief Summary

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The primary objective of this study is to establish a control population to assess performance of an investigational diagnostic test targeting lung neoplasms.

Detailed Description

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Subjects will be participating in a lung cancer screening program at enrollment. Subjects will have a blood sample collected within 60 days of a low-dose CT scan (LDCT). Subjects with nodules present on the LDCT or subjects with a clean LDCT scheduled for a 12-month follow-up may have another blood draw at 12 months.

Conditions

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Healthy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Lung Cancer Screening Patients - No Nodules

Subjects in an low dose CT screening program that present no nodules.

Blood Sample Collection

Intervention Type OTHER

Subjects participating in the study will have blood sample collected at enrollment. . For any subjects scheduled for a 12 month follow-up, additional blood samples will be collected at 12 months from enrollment.

Lung Cancer Screening Patients - Nodules

Subjects in an low dose CT screening program that present nodules. Additional follow-up data will be collected for up to 12 months and an additional blood sample collected

Blood Sample Collection

Intervention Type OTHER

Subjects participating in the study will have blood sample collected at enrollment. . For any subjects scheduled for a 12 month follow-up, additional blood samples will be collected at 12 months from enrollment.

Interventions

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Blood Sample Collection

Subjects participating in the study will have blood sample collected at enrollment. . For any subjects scheduled for a 12 month follow-up, additional blood samples will be collected at 12 months from enrollment.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Subject is male or female, 50 years of age or older.
2. Subject meets one of two lung cancer screening criteria below.

2. Subject has had previous LDCT scan(s) for lung cancer screening and the most recent LDCT scan prior to enrollment is negative for pulmonary nodules (Lung-RADS category 1, no nodules).
3. Subject understands the study procedures and is able to provide informed consent to participate in the study and authorization for release of relevant protected health information to the study Investigator.

Exclusion Criteria

1. Subjects with pulmonary nodules on the most recent LDCT scan prior to enrollment (Lung-RADS category 1 nodules with specific calcifications such as complete, central, popcorn, concentric rings and fat containing nodules are excluded).
2. Prior history of cancer within the past 5 years except for non-melanoma skin cancer.
3. Prior removal of the lung, excluding percutaneous lung biopsy.
4. Individual has a condition the Investigator believes would interfere with his or her ability to provide informed consent, comply with the study protocol, which might confound the interpretation of the study results or put the person at undue risk.
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Exact Sciences Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Laura Strong

Role: STUDY_DIRECTOR

Exact Sciences

Locations

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Achieve Clinical Research

Birmingham, Alabama, United States

Site Status

Phoenix Medical Group

Peoria, Arizona, United States

Site Status

Highlands Oncology Group

Springdale, Arkansas, United States

Site Status

NewportNativeMD, Inc.

Newport Beach, California, United States

Site Status

Palmtree Clinical Research, Inc.

Palm Springs, California, United States

Site Status

International Research Partners, LLC

Doral, Florida, United States

Site Status

Clinical Trials of Florida, LLC

Miami, Florida, United States

Site Status

Sarkis Clinical Trials

Ocala, Florida, United States

Site Status

Sarasota Memorial Hospital

Sarasota, Florida, United States

Site Status

Pasadena Center for Medical Research, Inc.

St. Petersburg, Florida, United States

Site Status

UnityPoint Health - St. Luke's Hospital

Cedar Rapids, Iowa, United States

Site Status

Meritus Center for Clinical Research

Hagerstown, Maryland, United States

Site Status

Lahey Clinic, Inc.

Burlington, Massachusetts, United States

Site Status

Boone Hospital Center

Columbia, Missouri, United States

Site Status

Creighton University

Omaha, Nebraska, United States

Site Status

Pulmonary Ultimate Research Experience, LLC

Toms River, New Jersey, United States

Site Status

Northwell Health Physicians Pulmonary Medicine

Manhasset, New York, United States

Site Status

Gotham Cardiovascular Research, PC

New York, New York, United States

Site Status

Clinical Trials Developers, Inc.

Milford, Ohio, United States

Site Status

Chest Diseases of Northwestern PA

Erie, Pennsylvania, United States

Site Status

Allegheny Health Network

Pittsburgh, Pennsylvania, United States

Site Status

Research Protocol Management Specialists

Pittsburgh, Pennsylvania, United States

Site Status

Safe Harbor Clinical Research

East Providence, Rhode Island, United States

Site Status

Anderson Pharmaceutical Research, LLC

Anderson, South Carolina, United States

Site Status

Charleston Research Institution

Charleston, South Carolina, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Clinical Research of Charleston

Mt. Pleasant, South Carolina, United States

Site Status

South Carolina Pharmaceutical Research

Spartanburg, South Carolina, United States

Site Status

Union Pharmaceutical Research

Union, South Carolina, United States

Site Status

Pulmonary Associates of Richmond, Inc.

Richmond, Virginia, United States

Site Status

ProHealth Care

Waukesha, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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2016-11

Identifier Type: -

Identifier Source: org_study_id

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