Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer
NCT ID: NCT01414595
Last Updated: 2017-06-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
248 participants
OBSERVATIONAL
2012-03-31
Brief Summary
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PURPOSE: This research trial studies tissue samples from patients with non-small cell lung cancer.
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Detailed Description
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* To identify and characterize single nucleotide variations (SNVs) in non-small cell lung cancer (NSCLC) specimens.
* To identify and characterize structural variations in the genomes of NSCLC specimens.
* To identify and characterize other genomic alterations including, but not limited to, expression profiling and methylation.
OUTLINE: DNA and RNA extracted from archived specimens are analyzed for single nucleotide variations, structural variations in the genomes, and other genomic alterations including, but not limited to, gene expression profiling and methylation. Clinical data related to disease, treatment, and recurrence from each patient sample is also collected.
Conditions
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Study Design
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CASE_ONLY
RETROSPECTIVE
Study Groups
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Group 1
CALGB 140202 outlines the standard procedures for sample procurement. Samples to be used for this project have already been obtained and are currently banked at the CALGB Pathology Coordinating Office (PCO) and the Lung Cancer Tissue Bank at Brigham and Women's Hospital.
DNA analysis
DNA methylation analysis
RNA analysis
gene expression analysis
polymorphism analysis
laboratory biomarker analysis
medical chart review
Interventions
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DNA analysis
DNA methylation analysis
RNA analysis
gene expression analysis
polymorphism analysis
laboratory biomarker analysis
medical chart review
Eligibility Criteria
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Inclusion Criteria
18 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
Alliance for Clinical Trials in Oncology
OTHER
Responsible Party
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Principal Investigators
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Ramaswamy Govindan, MD
Role: STUDY_CHAIR
Washington University School of Medicine
Locations
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Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center
Los Angeles, California, United States
Tunnell Cancer Center at Beebe Medical Center
Lewes, Delaware, United States
CCOP - Christiana Care Health Services
Newark, Delaware, United States
Greenebaum Cancer Center at University of Maryland Medical Center
Baltimore, Maryland, United States
Union Hospital of Cecil County
Elkton, Maryland, United States
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
St Louis, Missouri, United States
Cancer Institute of New Jersey at Cooper - Voorhees
Voorhees Township, New Jersey, United States
Roswell Park Cancer Institute
Buffalo, New York, United States
Duke Cancer Institute
Durham, North Carolina, United States
Rhode Island Hospital Comprehensive Cancer Center
Providence, Rhode Island, United States
Miriam Hospital
Providence, Rhode Island, United States
Countries
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Other Identifiers
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CALGB-151107
Identifier Type: -
Identifier Source: secondary_id
CDR0000706375
Identifier Type: REGISTRY
Identifier Source: secondary_id
CALGB-151107
Identifier Type: -
Identifier Source: org_study_id
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