Epicardial Stimulation of the Cardiac Autonomic Nervous System
NCT ID: NCT05255952
Last Updated: 2024-09-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
4 participants
INTERVENTIONAL
2022-08-16
2023-11-13
Brief Summary
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Proof of concept study
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Detailed Description
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Electrical stimulation of the cardiac plexus directly at the level of the heart allows simultaneous stimulation of the sympathetic and parasympathetic systems, whose complementary and not automatically antagonistic role is now recognized. Thus, direct stimulation of the plexus would optimize cardiac function in the short and long term by instantly improving cardiac output and decreasing pulmonary resistance as described in dogs by Kobayashi et al.
The objective of the EpiCANS study is to evaluate this technique in humans during cardiac surgery.
Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Patients
3 cycles of electrical stimualtions will be done at the end of cardiac surgery, before end of surgery (patient closure), under anaesthesia.
Cardiac outcomes will be monitored
Electrical stimulation
Electrical stimulation of the cardiac plexus
Interventions
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Electrical stimulation
Electrical stimulation of the cardiac plexus
Eligibility Criteria
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Inclusion Criteria
* Having received written and oral information about the protocol and having signed a written informed consent
* Affiliated or beneficiary of a social security plan
Exclusion Criteria
* Urgent or semi-urgent
* Aortic surgery
* Heart transplantation
* Mechanical circulatory assistance
* Patients who have already undergone cardiac surgery
* Adults under legal protection (safeguard of justice, curatorship, guardianship), persons deprived of liberty, pregnant or breastfeeding women, minors, persons unable to express their consent, persons hospitalized for a different reason
18 Years
ALL
No
Sponsors
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Rennes University Hospital
OTHER
Responsible Party
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Principal Investigators
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Karl BOU NADER, Dr
Role: STUDY_DIRECTOR
CHU Rennes
Locations
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CHU Rennes
Rennes, , France
Countries
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Other Identifiers
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35RC21_8946_04_EpiCANS
Identifier Type: -
Identifier Source: org_study_id
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