Non-invasive Modulation of Autonomic Cardiac Nervous System
NCT ID: NCT04057508
Last Updated: 2019-08-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2019-06-19
2019-12-31
Brief Summary
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Detailed Description
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Second part: Acquisition of the MSNA signal during non-invasive VNS and apnea. Non-invasive VNS is performed using several frequencies of stimulation. Maximal and voluntaries apnea are performed at the end of the expiration.
Continuous recording of the following parameters:
* non-invasive arterial blood pressure
* R-R interval
* electrocardiogram
* MSNA activity
* respiratory curve signal
* respiratory rate, oxygen saturation
Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
DOUBLE
Volunteers are blinded to the site of stimulation.
Study Groups
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Stimulation protocol
Each subject will be blinded and underwent 3 phases of stimulation (actives (2) and sham (1) comparators) in a randomized order .
Modulation of muscle sympathetic nerve activity
Assessment of muscle sympathetic nerve signal and exposition to external non invasive modulation.
Sham stimulation protocol
Each subject will be blinded and underwent 3 phases of stimulation (actives (2) and sham (1) comparators) in a randomized order.
Modulation of muscle sympathetic nerve activity
Assessment of muscle sympathetic nerve signal and exposition to external non invasive modulation.
Interventions
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Modulation of muscle sympathetic nerve activity
Assessment of muscle sympathetic nerve signal and exposition to external non invasive modulation.
Eligibility Criteria
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Inclusion Criteria
* \>18 years old
Exclusion Criteria
* smoke
* alcool/energy drinks/coffee consumption, exertion 24h before the participation
18 Years
ALL
Yes
Sponsors
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Erasme University Hospital
OTHER
Université Catholique de Louvain
OTHER
Responsible Party
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Locations
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Erasme University Hospital
Brussels, , Belgium
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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TFE_201904_097
Identifier Type: -
Identifier Source: org_study_id
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