Association Between Stroke and Adrenal Incidentalomas

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

2 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-01

Study Completion Date

2029-02-28

Brief Summary

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Adrenal incidentalomas (AIs) are commonly encountered in transsection imaging which purpose not for suspected adrenal disease. However, part of AIs in patients is associated with Stroke. Stroke is a diseases which could cause of disability and death worldwide. In clinical practice, detailed information about the association between stroke and AIs is not available. In this study, the investigators aimed to investigate the risk for disability and death in the large group of stroke patients with AIs.

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Detailed Description

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Background:

Adrenal incidentalomas (AIs) are commonly encountered in transsection imaging which purpose not for suspected adrenal disease. However, part of AIs in patients is associated with Stroke . The investigators aimed to investigate the risk for disability and death in the large group of stroke patients with AIs.

Objective:

To measure the association between stroke and levels of autonomous cortisol secretion in patients with AIs.

Design:

Part 1, Retrospective cohort study.

From April 1, 2021, to September 30, 2021, cohort patients with stroke were recruited in this study. The investigators assess the standardised incidence rate of AIs in all patients. Meanwhile, detail information about stroke disease、patient and AIs characteristics were record.

Part 2, Prospective cohort study.

From Mar 1, 2022, to Feb 29, 2024, cohort patients with stroke plane to recruit in this study. All patient receive the plasma cortisol level after a 1-mg dexamethasone suppression test. The investigators assess the standardised incidence rate of AIs in all patients. Meanwhile, detail information about stroke disease、patient and AIs characteristics would be record.

Conditions

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Stroke Adrenal Incidentaloma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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Cerebral infarction Group

Patients with cerebral infarction, and enrolled in our emergency or clinical department.

No interventions assigned to this group

Intracerebral hemorrhage Group

Patients with intracerebral hemorrhage, and enrolled in our emergency or clinical department.

No interventions assigned to this group

Subarachnoid hemorrhage Group

Patients with subarachnoid hemorrhage, and enrolled in our emergency or clinical department.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* stroke disease , such as Cerebral infarction、Intracerebral hemorrhage and Subarachnoid hemorrhage.

Exclusion Criteria

* presence of metastatic cancer;
* AIs smaller than 1 cm;
* nonadenoma lesions, such as myelolipomas,hemorrhages, and cysts;
* oral glucocorticoid treatment with more than single doses in the past 3 months;
* use of inhaled steroids or medication affecting dexamethasone metabolism;
* systemic estrogen treatment.

Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No