Human Milk in Preterm Infants

NCT ID: NCT05228535

Last Updated: 2022-07-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-04-11

Study Completion Date

2023-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Current NICU protocol introduces human milk fortifier at 8 days of feeding. This study will introduce human milk fortifier at day 1. The primary outcome is the effect on growth velocity at 28 days and 36 weeks post menstrual age.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Preterm Birth

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

2 groups. 1 group will be controlled, following standard NICU feeding protocol. 1 group will be intervention, receiving early introduction of human milk fortifier to enteral feeds.
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Control

Continue current NICU feeding protocol, introducing human milk fortifier at 8 days

Group Type NO_INTERVENTION

No interventions assigned to this group

Intervention

Introducing human milk fortifier at 1 day

Group Type EXPERIMENTAL

Human milk fortifier

Intervention Type DIETARY_SUPPLEMENT

Human milk fortifier added to human breast milk at day 1 vs day 8 of feeds

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Human milk fortifier

Human milk fortifier added to human breast milk at day 1 vs day 8 of feeds

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Birth weight 1000-1500 grams
* Admitted to NICU within 24 hours of life
* Maternal intent to use human milk

Exclusion Criteria

* Congenital anomalies
* Feeds not started within the first 96 hours of life
* Intrauterine growth restriction
Maximum Eligible Age

4 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Augusta University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Children's Hospital of Georgia

Augusta, Georgia, United States

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

United States

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Zanna Wynter, DO

Role: CONTACT

770-608-0868

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Zanna Wynter, DO

Role: primary

References

Explore related publications, articles, or registry entries linked to this study.

Wynter Z, Gorham JA, Thompson AB, Mundy C, Waller JL, Stansfield BK. Immediate fortification of human milk with a bovine milk-derived human milk fortifier in very low birth weight infants: a randomized clinical trial. J Perinatol. 2024 Nov;44(11):1591-1596. doi: 10.1038/s41372-024-01998-0. Epub 2024 May 9.

Reference Type DERIVED
PMID: 38724605 (View on PubMed)

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

1813934-2

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Preterm Infants Fed a Human Milk Fortifier
NCT05551975 NOT_YET_RECRUITING NA
Preemie Milk Analyser Validation Study
NCT06486194 NOT_YET_RECRUITING NA