Evaluation of a Novel Human Milk Fortifier in Preterm Infants

NCT ID: NCT01373073

Last Updated: 2013-02-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

147 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-08-31

Study Completion Date

2012-12-31

Brief Summary

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The purpose of this study is to assess growth of preterm infants fed human milk supplemented with an experimental human milk fortifier.

Detailed Description

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Conditions

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Preterm Infants

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Experimental Human Milk Fortifier

Experimental human milk fortifier to be added to human milk

Group Type EXPERIMENTAL

Experimental human milk fortifier

Intervention Type OTHER

Human milk fortifier to be added to human milk feedings

Control Human Milk Fortifier

Control human milk fortifier to be added to human milk

Group Type ACTIVE_COMPARATOR

Control human milk fortifier

Intervention Type OTHER

Control human milk fortifier to be added to human milk

Interventions

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Experimental human milk fortifier

Human milk fortifier to be added to human milk feedings

Intervention Type OTHER

Control human milk fortifier

Control human milk fortifier to be added to human milk

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 700-1500g birth weight
* 33 weeks or less gestational age
* Appropriate for gestational age
* Initiate enteral feeds of human milk by 21 days of life
* Mother provided exclusive human milk feeds
* Parents allow both human milk and study human milk fortifier
* Singleton or twin birth

Exclusion Criteria

* Feeding preterm infant formula or non-study human milk fortifier
* Expected at facility less than 15 days
* Congenital anomalies/disease affecting growth and development
* 5 minute APGAR of 4 or less
* Steroid use
* ECMO
* Grade III or IV PVH/IVH
* Mechanical ventilator dependency
* Maternal incapacity
* History of major surgery
* Asphyxia
* Confirmed NEC or sepsis
* Use of probiotics
Maximum Eligible Age

21 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Nutrition

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bridget Barrett-Reis, PhD

Role: STUDY_CHAIR

Abbott Nutrition

Locations

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University of Alabama

Birmingham, Alabama, United States

Site Status

UCSD Medical Center

San Diego, California, United States

Site Status

University South Florida

Tampa, Florida, United States

Site Status

Memorial Hospital of Southbend

Southbend, Indiana, United States

Site Status

Wesley Medical Center

Wichita, Kansas, United States

Site Status

King's County Hospital Center

Brooklyn, New York, United States

Site Status

Cohen Children's Medical Center of New York at North Shore

Manhasset, New York, United States

Site Status

Cohen Children's Medical Center of NY at North Shore

New Hyde Park, New York, United States

Site Status

Childrens Hospital Westchester Medical Center

Valhalla, New York, United States

Site Status

University Hospitals Case Medical Center Rainbow Babies & Children's Hospital

Cleveland, Ohio, United States

Site Status

MetroHealth Medical Center

Cleveland, Ohio, United States

Site Status

Toledo Children's Hospital

Toledo, Ohio, United States

Site Status

OHSU

Portland, Oregon, United States

Site Status

Lehigh Valley Health Network

Allentown, Pennsylvania, United States

Site Status

University of Utah

Salt Lake City, Utah, United States

Site Status

Countries

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United States

References

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Kim JH, Chan G, Schanler R, Groh-Wargo S, Bloom B, Dimmit R, Williams L, Baggs G, Barrett-Reis B. Growth and Tolerance of Preterm Infants Fed a New Extensively Hydrolyzed Liquid Human Milk Fortifier. J Pediatr Gastroenterol Nutr. 2015 Dec;61(6):665-71. doi: 10.1097/MPG.0000000000001010.

Reference Type DERIVED
PMID: 26488118 (View on PubMed)

Other Identifiers

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AK37

Identifier Type: -

Identifier Source: org_study_id

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