Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2021-04-09
2021-07-13
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SEQUENTIAL
OTHER
NONE
Study Groups
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Main study arm
Patients received intervention 1 and then intervention 2 after 7 weeks
Dark chocolate
Patients were administered 20 grams of dark chocolate
Milk Chocolate
Patients were administered 7.5 grams of milk chocolate
Interventions
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Dark chocolate
Patients were administered 20 grams of dark chocolate
Milk Chocolate
Patients were administered 7.5 grams of milk chocolate
Eligibility Criteria
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Inclusion Criteria
* Healthy volunteers
* No vascular diseases
* No ocular diseases
* Volunteers capable of understanding informed consent
Exclusion Criteria
* Patient unable to come back for follow-up
* opacity of lens, cornea, or vitreous
* Allergies that contraindicate pupil dilation
* Eye diseases
* Myopia greater than -8.0 Diopter (D),
* Hyperopia greater than 5.0 D
* Astigmatism greater than -3.0 D
18 Years
99 Years
ALL
Yes
Sponsors
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Querques Giuseppe
OTHER
Responsible Party
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Querques Giuseppe
Professor
Principal Investigators
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Francesco Bandello, MD
Role: PRINCIPAL_INVESTIGATOR
Ospedale San Raffaele
Locations
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Giuseppe Querques
Milan, , Italy
Countries
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References
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de Carlo TE, Romano A, Waheed NK, Duker JS. A review of optical coherence tomography angiography (OCTA). Int J Retina Vitreous. 2015 Apr 15;1:5. doi: 10.1186/s40942-015-0005-8. eCollection 2015.
Huang Y, Zhang Q, Thorell MR, An L, Durbin MK, Laron M, Sharma U, Gregori G, Rosenfeld PJ, Wang RK. Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms. Ophthalmic Surg Lasers Imaging Retina. 2014 Sep-Oct;45(5):382-9. doi: 10.3928/23258160-20140909-08.
McClintic SM, Jia Y, Huang D, Bailey ST. Optical coherence tomographic angiography of choroidal neovascularization associated with central serous chorioretinopathy. JAMA Ophthalmol. 2015 Oct;133(10):1212-4. doi: 10.1001/jamaophthalmol.2015.2126. No abstract available.
Siedlecki J, Mohr N, Luft N, Schworm B, Keidel L, Priglinger SG. Effects of Flavanol-Rich Dark Chocolate on Visual Function and Retinal Perfusion Measured With Optical Coherence Tomography Angiography: A Randomized Clinical Trial. JAMA Ophthalmol. 2019 Dec 1;137(12):1373-1379. doi: 10.1001/jamaophthalmol.2019.3731.
Rabin JC, Karunathilake N, Patrizi K. Effects of Milk vs Dark Chocolate Consumption on Visual Acuity and Contrast Sensitivity Within 2 Hours: A Randomized Clinical Trial. JAMA Ophthalmol. 2018 Jun 1;136(6):678-681. doi: 10.1001/jamaophthalmol.2018.0978.
Sacconi R, Pezzella M, Ribarich N, Menean M, Servillo A, Bandello F, Querques G. Benefits of dark chocolate intake on retinal vessels functionality: a randomized, blind, crossover clinical trial. Sci Rep. 2024 Aug 30;14(1):20203. doi: 10.1038/s41598-024-70289-7.
Related Links
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Nutrition Foundation of Italy
Other Identifiers
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FondazioneSanRaffaele
Identifier Type: -
Identifier Source: org_study_id
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