Clinical and Biochemical Evaluation of the Efficacy of Non-Surgical Treatment Approaches in the Treatment of Peri-implantitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

46 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-11-12

Study Completion Date

2022-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Peri-implantitis is a pathological condition associated with plaque that develops around dental implants, characterized by inflammation and progressive bone loss in the peri-implant area. Bleeding on probing, suppuration, increased pathological pocket depths and/or mucosal recessions are seen with radiographic bone loss in peri-implantitis. When evaluated histologically, the lesion extends to the apical part of the pocket epithelium and contains a large amount of plasma cells, macrophages and neutrophils. In the Peri-implant crevicular fluid analysis, which is one of the most important parameters that enable the biochemical and immunological evaluation of the inflammatory state in the peri-implant region, information about the current inflammatory situation can be obtained by evaluating the content of an osmotic inflammatory exudate originating from the vessels in the gingival plexus. Many surgical and non-surgical methods have been proposed for the treatment of peri-implantitis. Mechanical surface debridement, laser application and air abrasives are a part of non-surgical treatment of peri-implantitis. In this study, we examined the effectiveness of diode laser in addition to mechanical debridement with titanium curettes. In our study, we aimed to compare these two treatments biochemically by determining the changes in interleukin-1β, Interleukin-10, Interleukin-17, RANKL, osteoprotegerin, TWEAK and sclerostin biomarkers in Peri-implant crevicular fluid and clinically.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Evaluation of the Efficacy of Different Non-Surgical Peri-implantitis Treatment Approaches

NCT06849856

Periimplantitis

RECRUITING NA

Effect of Different Non-surgical Treatment Approaches of Peri-implantitis

NCT06730568

Peri-implant Inflammation Peri-Implantitis and Peri-implant Mucositis Non-surgical Treatment

COMPLETED NA

COMPARISION OF DIFFERENT TREATMENT METHODS OF PERI-IMPLANTITIS

NCT03241953

Peri-Implantitis Periodontal Diseases

COMPLETED NA

Peri-implant Phenotype, Calprotectin and Mmp-8 Levels in Cases Diagnosed With Peri-implant Disease

NCT06173739

Peri-implant Mucositis Peri-Implantitis

COMPLETED NA

Non-Surgical Treatment of Peri-Implantitis With Ultrasonic Carbon Tip

NCT06514677

Peri-Implantitis Alveolar Bone Loss

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Primary outcome measures (probing depth as clinical parameter) and secondary outcome measures ( collection of gingival crevicular fluid, gingival bleeding time index, gingival index, plaque index and clinical attachment level) asre recorded in baseline, third and sixth month. The change between these parameters is observed.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Peri-Implantitis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Diode Laser

At baseline, diode laser is applied to one group.

Group Type EXPERIMENTAL

Diode laser

Intervention Type DEVICE

Diode Laser is applied to one group as an adjunctive therapy.

Titanium curettes

Intervention Type DEVICE

Non-surgical treatment with titanium curettes were administrated to both groups.

Titanium curettes

At baseline, titanium curettes are used to both of the groups

Group Type ACTIVE_COMPARATOR

Titanium curettes

Intervention Type DEVICE

Non-surgical treatment with titanium curettes were administrated to both groups.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Diode laser

Diode Laser is applied to one group as an adjunctive therapy.

Intervention Type DEVICE

Titanium curettes

Non-surgical treatment with titanium curettes were administrated to both groups.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Presence of 5mm or more peri-implant pockets
* Not having periodontal treatment in the last 3 months,
* The informed consent form must be approved,
* At least 18 years old.

Exclusion Criteria

* Presence of systemic disease,
* Smoking,
* Regular use of non-steroidal anti inflammatory drugs,
* Having been treated with antibiotics in the last 3 months,
* Individuals in need of pre-treatment antibiotic prophylaxis,
* Pregnancy and lactation,
* Not approving the informed consent form,
* Patients with known allergies.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes