PERTRIAL - Perla® Preservation Solution

NCT ID: NCT05194306

Last Updated: 2023-05-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

11 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-12-11

Study Completion Date

2022-04-30

Brief Summary

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Perla® is a Cold Preservation Solution, with purpose to wash out, preserve during transport liver and kidney grafts in optimal conditions from the donor to the recipient.

The purpose of the PERTRIAL clinical investigation is to demonstrate the Performance and Safety of Perla® Cold Preservation solution.

Detailed Description

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Conditions

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Organ Transplant Ischemic Reperfusion Injury

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Perla® Cold Preservation solution

Perla® is a Cold Preservation Solution, with purpose to wash out, preserve during transport liver and kidney grafts in optimal conditions from the donor to the recipient.

Group Type EXPERIMENTAL

Perla® Cold Preservation solution

Intervention Type DRUG

Perla® must be cooled to 2° to 6 °C prior to use. The cold Preservation Solution is used to flush the isolated organ immediately before removal from the donor and/or immediately after removal from the donor. The solution is then left in the organ vasculature during hypothermic storage and transportation.

Interventions

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Perla® Cold Preservation solution

Perla® must be cooled to 2° to 6 °C prior to use. The cold Preservation Solution is used to flush the isolated organ immediately before removal from the donor and/or immediately after removal from the donor. The solution is then left in the organ vasculature during hypothermic storage and transportation.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Donor kidney / liver suitable for preservation
* Donor age equal or over 18 years old
* Donor meets one of the following conditions:
* Donor after brain death (DBD), standard and extended criteria (SCD \& ECD)
* Donor after circulatory death (DCD), cardiac arrest Maastricht classification III (awaiting cardiac arrest, controlled)


* Patient registered primary kidney or liver transplant candidate, male or female
* Patient ages ≥ 18 years old
* Patient who has signed written informed consent

Exclusion Criteria

* Donor participating at the same time in another Clinical Investigation

Recipient eligibility criteria:


Patient recipient will not be included if any of the following conditions exists:

* Prior solid organ or bone marrow transplant
* Multi-organ transplant
* Contraindications to transplantation (Active infection, active malignancy, pregnant females, females intending to get pregnant, or not willing to use a secure contraceptive method)
* Participation in another clinical trial
* Patient unable to give consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Complexo Hospitalario Universitario de A Coruña

OTHER

Sponsor Role collaborator

Advanced Life Solutions

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Centro Hospitalario Universitario A Coruña (CHUAC)

A Coruña, , Spain

Site Status

Countries

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Spain

Other Identifiers

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CIP001A

Identifier Type: -

Identifier Source: org_study_id

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