Does Homebrewing Beer Affect Urinary Tract Symptoms and Bladder Cancer

NCT ID: NCT05134675

Last Updated: 2022-02-24

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 500 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-06-16
• Study Completion Date: 2022-12-30

Brief Summary

In this study, investigators aim to reveal the harmful effects of increasing consumption of homemade beer in recent years on the urinary tract. The high amount of carbonyl compounds in the content of homemade beer has been proven by studies. In this study, which will be conducted in the form of a questionnaire, it is aimed to evaluate the effects of the consumption of homemade beer and the long-term exposure of the urinary system to carbonyl compounds.

Detailed Description

Homemade and craft beers are perceived as a popular alternative to beers produced on a larger scale in recent years, due to the choice of consumers according to different taste preferences and the raw materials used for brewing. According to nationally representative survey data from the American Homebrewers Association (AHA), the U.S. had an estimated 1.1 million homebrew brewers in 2017, with annual homebrew beer production in excess of 1.4 million barrels (about 1% of annual U.S. beer production). Again in 2017, 40% of home brewers started production within the last 4 years. Due to the prohibitions that have arisen due to the pandemic all over the world, the production of homemade beer has reached its peak today. In recent years, home-made beer consumption has gained popularity in parallel with low-alcohol and non-alcoholic beers, which are prone to microbial spoilage, due to the ease of access to the material, financial returns and hobby acquisition.

Homemade beer is typically more susceptible to spoilage as it is not pasteurized or sterile filtered. The microbiota, which is associated with organic raw materials, fruits, herbs, honey, spices and vegetables, and non-traditional starch-rich ingredients added to produce different aromas and flavors, increases the risk of spoilage. In addition, home brewers often lack the advantages of a sophisticated microbiological laboratory, and optimal temperature control during brewing and storage cannot be guaranteed. In addition to the fermentation conditions (time and temperature), yeast strain and mash composition (types of grain used in malting, mashing/boiling conditions) can also affect the chemical profile of beer, resulting in a wide variety of components. Carbonyl compounds [acetaldehyde, acrolein, ethyl carbamate (EC) and formaldehyde] are particularly toxic compounds that can occur. Acetaldehyde, acrolein, and formaldehyde are highly reactive due to their electrophilic nature, so they easily react with biological nucleophilic targets such as proteins, RNA, and DNA.

Conditions

Addiction, Alcohol; Urinary Tract Disease

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Consumption

Patients consuming homemade beer

Homemade beer

Intervention Type: DIETARY_SUPPLEMENT

The data of patients who consume and do not consume homemade beer will be cross-sectionally evaluated and compared.

Not consumption

Patients are not consuming homemade beer

Homemade beer

Intervention Type: DIETARY_SUPPLEMENT

The data of patients who consume and do not consume homemade beer will be cross-sectionally evaluated and compared.

Interventions

Homemade beer

The data of patients who consume and do not consume homemade beer will be cross-sectionally evaluated and compared.

Intervention Type: DIETARY_SUPPLEMENT

Other Intervention Names

Homebrewing beer

Eligibility Criteria

Inclusion Criteria

• Homemade beer consumption and not consumption

Exclusion Criteria

• Bleeding disorders

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Ankara Training and Research Hospital

OTHER

Sponsor Role: lead

Responsible Party

Ali Kaan Yildiz

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ali Kaan Yildiz

Role: PRINCIPAL_INVESTIGATOR

Ankara Training and Resarch Hospital

Locations

Ankara Training and Research Hospital

Ankara, Altindag, Turkey (Türkiye)

Countries

Turkey (Türkiye)

Central Contacts

Ali Kaan Yildiz

Role: CONTACT

alikaanyildiz@gmail.com

+90 554 773 16 96

Esra Gulen Yildiz

Role: CONTACT

esragln90@gmail.com

+90 506 877 47 09

References

Lachenmeier DW, Przybylski MC, Rehm J. Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach. Int J Cancer. 2012 Sep 15;131(6):E995-1003. doi: 10.1002/ijc.27553. Epub 2012 Apr 17.

Reference Type: RESULT

PMID: 22447328 (View on PubMed)

Other Identifiers

CB2021

Identifier Type: -

Identifier Source: org_study_id