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Identification of the Cranberry Juice Compounds That Prevent Urinary Tract Infections

NCT ID: NCT00087828

Last Updated: 2006-08-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2000-11-30

Study Completion Date

2005-06-30

Brief Summary

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The purpose of this study is to identify the substances in cranberry juice that make it effective in reducing urinary tract infections (UTIs) in women.

Detailed Description

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Urinary tract infections (UTIs) are a significant health issue, with one fourth of all women experiencing symptoms during their lifetimes. Cranberry juice has been shown to reduce the incidence of UTIs by preventing bacteria from adhering to the bladder. However, the compounds that direct this activity have not been identified. This study will identify and examine UTI-reducing compounds in cranberry juice.

Participants in this study will drink a specified amount of water following an overnight fast. Their urine will be collected 1 to 3 hours after the water is consumed. Several days later, the women will be provided with cranberry juice to replace the water in the regimen. Urine samples will be analyzed for compounds that have antibacterial or antiadhesion activity against the bacteria that cause UTIs.

Conditions

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Urinary Tract Infections

Keywords

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Vaccinium macrocarpon

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Interventions

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Cranberry juice cocktail

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Good overall health

Exclusion Criteria

* History of urinary tract infections
* Use of cranberry products or antibiotics within 1 week of study start
* Current use of any other medication
* Hypertension
* Diabetes
* Pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

64 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Center for Complementary and Integrative Health (NCCIH)

NIH

Sponsor Role lead

Principal Investigators

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Susan Turner, MD

Role: PRINCIPAL_INVESTIGATOR

UIC

Locations

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Dept Medicinal Chemistry & Pharmacognosy, COP, UIC

Chicago, Illinois, United States

Site Status

Countries

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United States

References

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Ahuja S, Kaack B, Roberts J. Loss of fimbrial adhesion with the addition of Vaccinum macrocarpon to the growth medium of P-fimbriated Escherichia coli. J Urol. 1998 Feb;159(2):559-62. doi: 10.1016/s0022-5347(01)63983-1.

Reference Type BACKGROUND
PMID: 9649291 (View on PubMed)

Avorn J, Monane M, Gurwitz JH, Glynn RJ, Choodnovskiy I, Lipsitz LA. Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA. 1994 Mar 9;271(10):751-4. doi: 10.1001/jama.1994.03510340041031.

Reference Type BACKGROUND
PMID: 8093138 (View on PubMed)

Foo LY, Lu Y, Howell AB, Vorsa N. A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli. J Nat Prod. 2000 Sep;63(9):1225-8. doi: 10.1021/np000128u.

Reference Type BACKGROUND
PMID: 11000024 (View on PubMed)

Foo LY, Lu Y, Howell AB, Vorsa N. The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro. Phytochemistry. 2000 May;54(2):173-81. doi: 10.1016/s0031-9422(99)00573-7.

Reference Type BACKGROUND
PMID: 10872208 (View on PubMed)

Schmidt DR, Sobota AE. An examination of the anti-adherence activity of cranberry juice on urinary and nonurinary bacterial isolates. Microbios. 1988;55(224-225):173-81.

Reference Type BACKGROUND
PMID: 3063927 (View on PubMed)

Other Identifiers

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F31AT000623

Identifier Type: NIH

Identifier Source: secondary_id

View Link

F31 AT000623-1

Identifier Type: -

Identifier Source: org_study_id