Peppermint Oil for the Treatment of Interstitial Cystitis / Bladder Pain Syndrome

NCT ID: NCT04845217

Last Updated: 2022-08-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE1/PHASE2

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-09-15

Study Completion Date

2023-12-31

Brief Summary

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The purpose of this study is to assess the use of peppermint oil as a treatment for Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS).

Detailed Description

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After being informed about the study and potential risks, all participants will complete validated IC/BPS symptom questionnaires for baseline screening. Once participants meet eligibility requirements and give written informed consent they will be randomized in a 1:1 ratio to peppermint oil (200mg TID) or placebo (also TID). Participants will complete validated IC/BPS questionnaires and follow up surveys over 8 weeks.

Conditions

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Interstitial Cystitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participants will be randomized in a 1:1 ratio to the intervention or placebo arm. Allocation concealment will be in place to ensure the individual enrolling the subject into the study has no a priori knowledge of group assignment. Block randomization will occur with randomly mixed block sizes of 4, 6, and 8 using the randomization list generator at www.sealedenvelope.com. Randomization information will be kept confidential and only available to study personnel.
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants
The peppermint-oil and placebo treatments will be kept in a locked and secured area of the office, in a room not used for patient care. The bottles will be de-identified, with labels detailing the specific instructions for how to take the soft gels and the number in each bottle. Each group will be instructed to take one soft gel three times daily.

The peppermint oil and placebo medications will be distributed by the research team. The manufacturer label will be covered up/removed and a study label stating the use of a study medication will be used to maintain patient blinding.

Study Groups

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Peppermint Oil

Participants in the intervention (peppermint oil) arm will receive soft gels of enteric-coated peppermint oil (0.2mL=200mg). The enteric coated peppermint oil soft gel utilized in this study is Peptogest Peppermint Oil from Schwabe North America (Nature's Way Brand).

Group Type EXPERIMENTAL

Peppermint oil

Intervention Type DRUG

Enteric coated peppermint oil taken by mouth three times daily for 8 weeks.

Coconut Oil

Participants in the placebo (coconut oil) arm will receive soft gels of enteric coated coconut oil. The enteric coated coconut oil soft gel utilized in this study is Coconut Oil from Schwabe North America (Nature's Way Brand).

Group Type PLACEBO_COMPARATOR

Coconut Oil

Intervention Type DRUG

Enteric coated coconut oil taken by mouth three times daily for 8 weeks

Interventions

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Peppermint oil

Enteric coated peppermint oil taken by mouth three times daily for 8 weeks.

Intervention Type DRUG

Coconut Oil

Enteric coated coconut oil taken by mouth three times daily for 8 weeks

Intervention Type DRUG

Other Intervention Names

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Peptogest Peppermint Oil Coconut Oil Pure Extra Virgin

Eligibility Criteria

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Inclusion Criteria

* Women ages 18-65 years old
* Diagnosed with IC/BPS for at least one month prior to study enrollment

Exclusion Criteria

* Culture proven urinary tract infection within 1 month of randomization
* Gross hematuria
* Currently pregnant or breastfeeding
* Unable to speak and read English
* History of allergic reaction to peppermint, coconut or enteric coating
* History of malabsorption syndrome
* History of gastroparesis
* History of gastric bypass surgery
* History of gastrointestinal, genitourinary or pelvic cancer in the last 5 years
* History of insulin dependent diabetes
* History of active urinary stone disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Integrative Therapeutics, Inc.

INDUSTRY

Sponsor Role collaborator

University of Louisville

OTHER

Sponsor Role lead

Responsible Party

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Sean Francis, MD

Professor, MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sean Francis, MD

Role: PRINCIPAL_INVESTIGATOR

Department Chair

Locations

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Springs Medical Center

Louisville, Kentucky, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Jenna Warehime, DO

Role: CONTACT

502-588-7660

Facility Contacts

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Sean Francis, MD

Role: primary

Other Identifiers

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21.0286

Identifier Type: -

Identifier Source: org_study_id

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