A Pilot Clinical Investigation of the Efficacy and Safety of Uracyst® Versus Placebo in Patients With Interstitial Cystitis/Painful Bladder Syndrome.

NCT ID: NCT00527917

Last Updated: 2009-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

65 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-09-30

Study Completion Date

2008-09-30

Brief Summary

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This is a pilot clinical investigation. Patients who meet the eligibility criteria and provide signed informed consent will be randomized to receive either an active product (Uracyst®) or placebo intravesically via a bladder catheter weekly for 6 weeks, followed by 6 weeks of follow-up period.

Detailed Description

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Conditions

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Interstitial Cystitis

Keywords

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IC/PBS Interstitial Cystitis/Painful Bladder Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Uracyst

Sodium chondroitin sulfate

Group Type EXPERIMENTAL

Uracyst

Intervention Type DEVICE

20 ml sterile solution for weekly intravesical instillation

Placebo

placebo

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DEVICE

bladder instillation

Interventions

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placebo

bladder instillation

Intervention Type DEVICE

Uracyst

20 ml sterile solution for weekly intravesical instillation

Intervention Type DEVICE

Other Intervention Names

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device vehicle sodium chondroitin sulfate

Eligibility Criteria

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Inclusion Criteria

* Are female of male patient 18 years or older
* Have been previously diagnosed with IC/PBS.
* Are willing to provide informed consent
* Available for the duration of the study including treatment and follow-up (12 weeks)

Exclusion Criteria

* Pregnant or lactating female.
* Are currently or have previously received investigational drugs within thirty (30) days of screening.
* Previous therapy for IC/PBS
* Have any medical condition/disease that could interfere with patient compliance or interfere with interpretation of the study results.
* Are unable or unwilling to comply with protocol requirements
* Are unable to read, understand, and provide written informed consent.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Watson Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Watson Laboratories Inc

Principal Investigators

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Keshava Kumar, PhD

Role: STUDY_DIRECTOR

Watson Pharmaceuticals

Locations

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Surrey, British Columbia, Canada

Site Status

Vancouver, British Columbia, Canada

Site Status

Victoria, British Columbia, Canada

Site Status

Kentville, Nova Scotia, Canada

Site Status

Barrie, Ontario, Canada

Site Status

Brantford, Ontario, Canada

Site Status

Guelph, Ontario, Canada

Site Status

Kingston, Ontario, Canada

Site Status

Kitchener, Ontario, Canada

Site Status

Newmarket, Ontario, Canada

Site Status

North Bay, Ontario, Canada

Site Status

Thunder Bay, Ontario, Canada

Site Status

Toronto, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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UR07001

Identifier Type: -

Identifier Source: org_study_id