Contribution of an Off-the-shelf Carbon Ankle Foot Orthosis (AFO) in the Management of Walking Functional Impairment

NCT ID: NCT05131399

Last Updated: 2024-09-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-28

Study Completion Date

2024-11-30

Brief Summary

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The objective of this study is to assess the superiority in achieving personal goals (set by the patient and the medical team) according to the GAS scale (Goal Attainment Scaling) while wearing the carbon medical device Ankle Foot Orthosis (AFO) compared to a standard plastic ankle foot orthosis.

Detailed Description

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Foot drop is a symptom observed in various pathologies including neuro-muscular pathologies of peripheral or central origin. It is a walking disability, causing a deterioration in the patients autonomy and quality of life.

The current medical strategy focuses on various off-the-shelf or custom made devices, depending on the walking functional impairment and the characteristics of foot deformities.

The objective of this study is to assess the superiority in achieving personal goals (set by the patient and the medical team) according to the GAS scale (Goal Attainment Scaling) while wearing the carbon medical device ankle foot orthosis compared to a standard plastic ankle foot orthosis.

Conditions

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Neuropathy (Disorder)

Study Design

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Allocation Method

NA

Intervention Model

SEQUENTIAL

Prospective, multicenter, interventional study, SCED design in ABAB introduction/withdrawal. The timing of the transition from one phase to the next will be randomized. The duration of each of the phases (A1, B1, A2, B2) will therefore be defined randomly, while maintaining a total duration of 12 weeks for each study schema.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Self-comparison

Patients will be fitted with 2 types of ankle foot orthoses, alternately, divided into 4 phases, in the following order:

Phase A1: Standard Plastic ankle foot orthosis Phase B1: carbon medical device ankle foot orthosis Phase A2: Standard Plastic ankle foot orthosis Phase B2: carbon medical device ankle foot orthosis Each patient is his own comparator. For all patients, the total duration of the study will be the same, and will correspond to 12 weeks.

Group Type EXPERIMENTAL

Phase A1

Intervention Type DEVICE

Plastic standard ankle foot orthosis

Phase B1

Intervention Type DEVICE

carbon medical device ankle foot orthosis

Phase A2

Intervention Type DEVICE

Plastic standard ankle foot orthosis

Phase B2

Intervention Type DEVICE

carbon medical device ankle foot orthosis

Interventions

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Phase A1

Plastic standard ankle foot orthosis

Intervention Type DEVICE

Phase B1

carbon medical device ankle foot orthosis

Intervention Type DEVICE

Phase A2

Plastic standard ankle foot orthosis

Intervention Type DEVICE

Phase B2

carbon medical device ankle foot orthosis

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient with a foot levator muscles impairment (single or bilateral drop foot) and / or instability of the back of the foot, associated with a deficit of the triceps
* Patient with inability to stand on tip-toe on one foot
* Patient having signed a free and informed consent
* Patient affiliated or entitled to a social security scheme

Exclusion Criteria

* Patient with fixed varus-equine foot
* Patient with an unstable skin condition (whether or not treated with additional treatment that may change the footwear)
* Patient with a a foot levator muscles impairment with a deficiency of the quadriceps and hamstrings (knee involvement)
* Patient with uncontrolled spasticity
* Patient for whom foot surgery is planned during the study
* Patient with one of the contraindications to the use of carbon medical device, indicated in the instructions for use
* Patient with one of the contraindications to the use of the standard plastic ankle foot orthosis, indicated in the instructions for use
* Patient with orthopedic comorbidities affecting the musculoskeletal system
* Pregnant woman
* Patient with major cognitive impairment incompatible with participation in a clinical trial
* Patient participating in another clinical investigation conducted to establish the compliance of a MD impacting the evaluation criteria
* Patient who cannot be followed for 12 weeks
* Vulnerable patient according to article L1121-6 of the public health code, persons subject to a measure of judicial protection or unable to consent freely
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Thuasne

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Philippe THOUMIE, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Hôpital Rothschild (Paris)

Locations

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Ch Les Capucins

Angers, , France

Site Status RECRUITING

Chu Dijon

Dijon, , France

Site Status RECRUITING

CH LAVAL

Laval, , France

Site Status RECRUITING

CHU Lille

Lille, , France

Site Status RECRUITING

centre Louis PIERQUIN

Nancy, , France

Site Status NOT_YET_RECRUITING

CHU Nantes

Nantes, , France

Site Status RECRUITING

Hôpital Rothschild

Paris, , France

Site Status RECRUITING

CHU Strasbourg

Strasbourg, , France

Site Status NOT_YET_RECRUITING

Countries

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France

Central Contacts

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Philippe THOUMIE, MD PhD

Role: CONTACT

(0)140193534 ext. +33

Astrid PICOLET

Role: CONTACT

(0)640392490 ext. +33

Facility Contacts

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Yoann Ronzi, MD

Role: primary

Nawale HADOUIRI, MD

Role: primary

Romain Champagne, MD

Role: primary

Vincent TIFFREAU, MD PhD

Role: primary

Isabelle LOIRET, MD

Role: primary

Raphaël Gross, PhD, MD

Role: primary

Philippe THOUMIE, MD PhD

Role: primary

(0)140193534 ext. +33

Amandine HELFER, MD

Role: primary

References

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Krasny-Pacini A, Evans J. Single-case experimental designs to assess intervention effectiveness in rehabilitation: A practical guide. Ann Phys Rehabil Med. 2018 May;61(3):164-179. doi: 10.1016/j.rehab.2017.12.002. Epub 2017 Dec 15.

Reference Type BACKGROUND
PMID: 29253607 (View on PubMed)

Barreto LC, Oliveira FS, Nunes PS, de Franca Costa IM, Garcez CA, Goes GM, Neves EL, de Souza Siqueira Quintans J, de Souza Araujo AA. Epidemiologic Study of Charcot-Marie-Tooth Disease: A Systematic Review. Neuroepidemiology. 2016;46(3):157-65. doi: 10.1159/000443706. Epub 2016 Feb 6.

Reference Type BACKGROUND
PMID: 26849231 (View on PubMed)

Gholizadeh H, Abu Osman NA, Eshraghi A, Ali S, Razak NA. Transtibial prosthesis suspension systems: systematic review of literature. Clin Biomech (Bristol). 2014 Jan;29(1):87-97. doi: 10.1016/j.clinbiomech.2013.10.013. Epub 2013 Oct 29.

Reference Type BACKGROUND
PMID: 24315710 (View on PubMed)

Zucker DR, Ruthazer R, Schmid CH. Individual (N-of-1) trials can be combined to give population comparative treatment effect estimates: methodologic considerations. J Clin Epidemiol. 2010 Dec;63(12):1312-23. doi: 10.1016/j.jclinepi.2010.04.020. Epub 2010 Sep 22.

Reference Type BACKGROUND
PMID: 20863658 (View on PubMed)

Spieler JF, Amarenco P. [Socio-economic aspects of stroke management]. Rev Neurol (Paris). 2004 Nov;160(11):1023-8. doi: 10.1016/s0035-3787(04)71139-x. French.

Reference Type BACKGROUND
PMID: 15602344 (View on PubMed)

Other Identifiers

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2021-A02115-36

Identifier Type: -

Identifier Source: org_study_id

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