Development and Validation of The Post-RT LARS Prediction Model (PORTLARS)
NCT ID: NCT05129215
Last Updated: 2022-11-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
901 participants
OBSERVATIONAL
2020-03-06
2022-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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Development
A primary cohort of eligible patients from the Sixth Affiliated Hospital of Sun Yat-sen University is used for model derivation.
Questionnaire
The LARS score is used for assessment of bowel dysfunction after rectal cancer resection.
Internal cross-validation
A cohort of consecutive patients from the Sixth Affiliated Hospital of Sun Yat-sen University is used for internal cross-validation.
Questionnaire
The LARS score is used for assessment of bowel dysfunction after rectal cancer resection.
External validation
An independent cohort of eligible patients from other hospitals is used for external validation.
Questionnaire
The LARS score is used for assessment of bowel dysfunction after rectal cancer resection.
Interventions
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Questionnaire
The LARS score is used for assessment of bowel dysfunction after rectal cancer resection.
Eligibility Criteria
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Inclusion Criteria
* Preoperative radiotherapy
Exclusion Criteria
* Metastasis or recurrence
* Postoperative radiotherapy
* Cognitive disorder
* Intestinal stoma
* Rectal cancer resection for \<12 months
* Stoma reversal for \<6 months
ALL
No
Sponsors
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Peking University Cancer Hospital & Institute
OTHER
Beijing Friendship Hospital
OTHER
Sixth Affiliated Hospital, Sun Yat-sen University
OTHER
Responsible Party
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Principal Investigators
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Qiyuan Qin, M.D.
Role: PRINCIPAL_INVESTIGATOR
Sixth Affiliated Hospital, Sun Yat-sen University
Locations
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Sixth Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
Countries
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References
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Qin Q, Huang B, Wu A, Gao J, Liu X, Cao W, Ma T, Kuang Y, Guo J, Wu Q, Shao B, Guan Q, Yao H, Zhang X, Wang H; Chinese Radiation Intestinal Injury Research Group. Development and Validation of a Post-Radiotherapy Prediction Model for Bowel Dysfunction After Rectal Cancer Resection. Gastroenterology. 2023 Dec;165(6):1430-1442.e14. doi: 10.1053/j.gastro.2023.08.022. Epub 2023 Aug 23.
Other Identifiers
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E2020016
Identifier Type: -
Identifier Source: org_study_id
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