Chemoradiotherapy After Surgery Versus Preoperative Chemoradiotherapy for Stage II/III Mid-low Rectal Cancer With or Without High-risk Factors
NCT ID: NCT06566222
Last Updated: 2024-08-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
2000 participants
OBSERVATIONAL
2024-08-25
2024-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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NAT+High
High-risk Factors
High-risk Factors vs low-risk Factors
NAT+Low
No interventions assigned to this group
PAT+High
chemoradiotherapy after surgery
chemoradiotherapy after surgery vs preoperative chemoradiotherapy
High-risk Factors
High-risk Factors vs low-risk Factors
PAT+Low
No interventions assigned to this group
Interventions
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chemoradiotherapy after surgery
chemoradiotherapy after surgery vs preoperative chemoradiotherapy
High-risk Factors
High-risk Factors vs low-risk Factors
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Adenocarcinoma confirmed by pathology;
3. Colonoscopy or imaging examination confirmed that the distance between the lower edge of the tumor and the anal margin is ≤10cm;
4. ECOG score ≤2
(4) Imaging diagnostic analysis was cT1-3NxM0; (for Phase II/III) (5) CT examination of the chest and abdomen and pelvis showed no evidence of metastasis (6) Patients undergoing chemoradiotherapy and surgery
Exclusion Criteria
2. Diagnosis of simultaneous multiple primary colorectal cancer or other cancers;
3. History of chemotherapy or radiotherapy prior to this trial
4. Those with contraindications to laparoscopic surgery, such as severe cardiopulmonary insufficiency;
5. Patients with intestinal obstruction, intestinal perforation, intestinal bleeding, etc., requiring emergency surgery;
6. Pregnant or lactating women;
7. Evidence of distant metastases prior to surgery
8. T4b tumors were found to invade the uterus, vagina, bladder, seminal vesicles, prostate, bone, and pelvic plexus
ALL
Yes
Sponsors
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Changhai Hospital
OTHER
Responsible Party
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Other Identifiers
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ChanghaiH-Radiotherapy
Identifier Type: -
Identifier Source: org_study_id
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