Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2021-11-22
2024-06-01
Brief Summary
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Whether dietary nitrate influences the enteral microbiome and downstream metabolites like short-chain fatty acids (SCFA) and TMAO will be investigated in the present study.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Study Groups
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Nitrate
Dietary inorganic nitrate (0,12 mmol sodium-nitrate/kg BW/day) dissolved in 200 ml tap water. Supplementation for 30 days.
Nitrate
Dietary inorganic nitrate (0,12 mmol sodium-nitrate/kg BW/day) dissolved in 200 ml tap water. Supplementation for 30 days.
Control
Dietary sodium-chloride (0,12 mmol sodium-chloride/kg BW/day) dissolved in 200 ml tap water. Supplementation for 30 days.
Control
Dietary sodium-chloride (0,12 mmol sodium-chloride/kg BW/day) dissolved in 200 ml tap water. Supplementation for 30 days.
Interventions
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Nitrate
Dietary inorganic nitrate (0,12 mmol sodium-nitrate/kg BW/day) dissolved in 200 ml tap water. Supplementation for 30 days.
Control
Dietary sodium-chloride (0,12 mmol sodium-chloride/kg BW/day) dissolved in 200 ml tap water. Supplementation for 30 days.
Eligibility Criteria
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Inclusion Criteria
* no regular medication intake
* no chronic diseases
Exclusion Criteria
* Active smoking
* Chronic diseases
* Acute diarrhea or vomiting
* Short gut syndrome
* Pregnancy or breastfeeding
40 Years
80 Years
ALL
Yes
Sponsors
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University Hospital, Essen
OTHER
Responsible Party
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Principal Investigators
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Tienush Rassaf, Professor
Role: STUDY_DIRECTOR
Clinic of cardiology and angiology, University Hospital Essen
Locations
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University Hospital Essen
Essen, North Rhine-Westphalia, Germany
Countries
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References
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Messiha D, Lange E, Tratnik A, M Westendorf A, Rinke M, Lenz S, Hendgen-Cotta UB, Buer J, Rassaf T, Rammos C. The influence of acute and chronic coronary syndrome on the gut microbiome and downstream microbiome-derived metabolites-Microbiome in acute myocardial infarction-MIAMI-Trial. Basic Res Cardiol. 2025 Oct;120(5):913-924. doi: 10.1007/s00395-025-01134-9. Epub 2025 Aug 13.
Other Identifiers
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Dietary nitrate and microbiome
Identifier Type: -
Identifier Source: org_study_id
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