Safety and Efficacy of HB-1 for Panic Disorder

NCT ID: NCT05071430

Last Updated: 2025-03-18

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 86 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-02-03
• Study Completion Date: 2022-12-12

Brief Summary

The purpose of this study is to determine the safety and efficacy of potential new treatment called "HB-1" versus placebo in male and female adult patients aged 18 to 60 years, inclusive, with panic disorder.

Detailed Description

This is a multicenter, randomized, double-blind, placebo-controlled trial. All patients with panic disorder, with or without specified co-morbidities, who meet all of the inclusion and none of the exclusion criteria will be eligible. Patients and researchers will be blinded to their treatment group.

The study will enroll approximately 80 adult patients who meet the diagnosis of panic disorder.

The patients will be treated for 12 weeks including a 1 week safety follow up visit following the last dose of study drug.

Conditions

Panic Disorder

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Active Treatment (HB-01)

Approximately 40 patients will receive HB-01 active study drug.

Group Type: ACTIVE_COMPARATOR

HB-01

Intervention Type: DRUG

HB-1 will be supplied as a dual active pharmaceutical ingredient tablet.

Placebo Treatment

Approximately 40 patients will receive a matched placebo.

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

HB-1 matched placebo

Interventions

HB-01

HB-1 will be supplied as a dual active pharmaceutical ingredient tablet.

Intervention Type: DRUG

Placebo

HB-1 matched placebo

Intervention Type: DRUG

Other Intervention Names

Active Drug

Eligibility Criteria

Inclusion Criteria

1. Male or female aged 18 to 60 years old, inclusive, at the time of informed consent.

2. Meets Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Criteria for Panic Disorder.

3. Documented moderate to severe levels of symptoms at baseline (Panic Disorder Severity Scale of 13 or above)

4. Medically stable on current medication regimen for at least 3 months including PRN ('as needed') medications as determined by Investigator.

5. Willing to remain on current doses of other psychiatric medications throughout the length of the trial (unless a dose reduction is warranted due to improvement in symptoms).

6. Willing and able to safely stop any of the following medications prior to study trial: Inhibitors or inducers of CYP3A4 (erythromycin, ritonavir, telithromycin, rifampin), HMG-CoA (hydroxy methylglutaric acid coagulase) Reductase Inhibitors (Simvastatin, Lovastatin, Atorvastatin), Beta Blockers (Timolol eyedrops, Metoprolol), Neuromuscular Blocking Agents (curare-like and depolarizing), Antihypertensive Agents (Prazosin and vasodilators, angiotensin-converting enzyme inhibitors, diuretics, beta blockers), Inhalation Anesthetics, Disopyramide, Flecainide, Quinidine, Cimetidine, Lithium, Carbamazepine, Phenobarbital, Cyclosporine, Digitalis, Aliskiren, Ramipril and Ramiprilat, aspirin.

7. Fluent in English.

8. Willing to take HB-1 or placebo.

9. Willing and able to provide informed consent indicating an understanding of the requirements of the study and a willingness to comply with scheduled visits and all study procedures.

10. Female patients must be surgically sterile (or have a monogamous partner who is surgically sterile) or be least 2 years postmenopausal or commits to use 2 acceptable forms of birth control (defined as the use of an intrauterine device, a barrier method with spermicide, condoms, any form of hormonal contraceptives, or abstinence) for the duration of the study and for 4 months following the last dose of study treatment. Male patients must be sterile (biologically or surgically) or commit to the use of a reliable method of birth control (condoms with spermicide) for the duration of the study and for 4 months following the last dose of study treatment. Individuals who are involved exclusively in same-sex relationships are exempt from the birth control requirements but must agree to abide by the recommendations if they do engage in a heterosexual relationship.

11. Female patients who are women of childbearing potential (WOCBP) must have a negative pregnancy test at Screening, within 7 days of dosing with study treatment.

Exclusion Criteria

1. Severe uncontrolled cardiac disease within 6 months of Screening, including but not limited to uncontrolled hypertension, hypotension (defined as below 90/60); unstable angina; myocardial infarction (MI) or cerebrovascular accident (CVA).

2. Any clinically significant electrocardiogram (ECG) abnormalities at screening.

3. Inadequate hepatic function defined as total bilirubin >1.5 × the upper limit of normal (ULN) ranges of each institution, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) >3 × the ULN range of each institution.

4. Inadequate renal function defined as serum creatinine >1.5 × the ULN range of each institution and/or estimated glomerular filtration rate (eGFR) <60.

5. Any clinically significant abnormalities in clinical laboratory assessments as assessed by the Investigator.

6. Any other systemic conditions or organ abnormalities that in the opinion of the Investigator may interfere with the conduct and/or interpretation of the current study.

7. Unable to complete neuropsychological testing.

8. Diagnosis of Bipolar I, Bipolar II disorder or Schizophrenia.

9. History of suicidal behaviors including ideation.

10. Current treatment with doses of benzodiazepines that are outside the FDA-approved prescriber's information.

11. Already on treatment with either telmisartan or verapamil or both.

12. Documented prior drug allergy to either telmisartan or verapamil.

13. Documented contraindication to taking telmisartan or verapamil: (eg, Duchenne's muscular dystrophy, myasthenia gravis).

14. Documented moderate to severe substance abuse within the last 6 months (recreational cannabis use is allowed).

15. Pregnant or breastfeeding.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cognitive Research Corporation

INDUSTRY

Sponsor Role: collaborator

Honeybrains Biotech LLC

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

David Walling

Role: PRINCIPAL_INVESTIGATOR

Collaborative NeuroScience Research, Garden Grove, CA

Locations

Collaborative Neuroscience Research

Garden Grove, California, United States

Lumos Psychiatric Services

San Jose, California, United States

Institute of Living

Hartford, Connecticut, United States

CNS Healthcare

Jacksonville, Florida, United States

CNS Healthcare

Orlando, Florida, United States

Uptown Research Institute

Chicago, Illinois, United States

Hassman Research Institute

Berlin, New Jersey, United States

SPRI Clinical Trials

Brooklyn, New York, United States

Richmond Behavioral Associates

Staten Island, New York, United States

CNS Healthcare

Memphis, Tennessee, United States

Countries

United States

Provided Documents

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

HB-001

Identifier Type: -

Identifier Source: org_study_id