Omics Sequencing of Exosomes in Body Fluids of Patients With Acute Lung Injury

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

180 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-05-06

Study Completion Date

2024-12-16

Brief Summary

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The exosomes in the experimental group and the control group were sequenced to find the difference of the two groups, providing a basis for subsequent basic research.

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Detailed Description

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This study is an observational study, mainly collected by infection, trauma, burns and other non cardiac causes without any related comprehensive character drug treatment of acute respiratory distress (ARDS) in patients with blood, urine or alveolar lavage fluid specimens, used to extract exosomes for omics sequencing, relevant histomorphic variations in exosomes of this disease were obtained, In addition, functional verification of genes or proteins with different changes will be carried out to provide clinical basis for subsequent basic research.

Conditions

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Acute Lung Injury

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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control group

Healthy people served as the control group

No interventions assigned to this group

experimental group

Patients with acute lung injury were treated as the experimental group.

The lungs causes and extrapulmonary factors

Intervention Type DIAGNOSTIC_TEST

Acute lung injury due to internal and external pulmonary causes can be used as intervention items in this study, and intervention items can be excluded according to inclusion criteria and exclusion criteria.

Interventions

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The lungs causes and extrapulmonary factors

Acute lung injury due to internal and external pulmonary causes can be used as intervention items in this study, and intervention items can be excluded according to inclusion criteria and exclusion criteria.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Signed informed consent voluntarily;
* Age: \>18 years old, gender: no restrictions ;
* Patients with known clinical manifestations of respiratory impairment or new/aggravated respiratory symptoms diagnosed within one week of onset according to the Berlin definition guidelines.

* Age ≥18 years old (including 18 years old), male and female;
* Male weight ≥50 kg, female weight ≥45kg, and body mass index (BMI) between 19 and 26(inclusive), BMI= weight (kg)/ height (㎡);
* No smoking, alcohol addiction, no history of drug abuse;
* No diabetes, asthma, copd, chronic renal insufficiency and other basic diseases; No history of major diseases or infectious diseases (including hepatitis B, hepatitis C, HIV, syphilis);
* Those who have not taken drugs recently.

Exclusion Criteria

* Patients with diabetes, chronic renal insufficiency, malignant tumors and other basic diseases;
* severe malnutrition;
* Pregnant or lactating women;
* The researcher judged that he was not suitable to participate in this study.

* pregnant or lactation women;
* severe malnutrition;
* The researcher judged that he was not suitable to participate in this study.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes