Efficiency and Safety of Microwave Ablation Plus Immune Checkpoint Inhibitor for Patients With Multiple Primary Lung Cancer: A Open, Multi-center, Phase II Clinical Trial

NCT ID: NCT05053802

Last Updated: 2021-09-23

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 146 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-03-21
• Study Completion Date: 2027-09-30

Brief Summary

Prospective, multi-center, phase II clinical trial. The study plans to enroll 146 patients with multiple lung cancers. After signing the informed consent, they were screened to meet the admission and discharge criteria, and received microwave ablation treatment. Electromagnetic navigation bronchoscope-guided intrapulmonary microwave ablation or percutaneous microwave ablation was selected according to the patient's wishes and the evaluation of the surgeon. After the operation, they were randomized and the experimental group accepted PD-1 immune checkpoint inhibitor treatment (microwave ablation combined with Camrelizumab treatment does not exceed 16 cycles, or disease progression/worsening or confirmed imaging disease progression, or withdrawal for any reason), the control group does not After receiving any treatment, the two groups were followed up closely (36 months after the last treatment, including safety follow-up and survival follow-up).

Conditions

Multiple Primary Lung Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Microwave ablation plus Camrelizumab

Microwave ablation plus Camrelizumab (no more than 16 cycles)

Group Type: EXPERIMENTAL

Microwave ablation plus Camrelizumab

Intervention Type: COMBINATION_PRODUCT

Tumor received treatment of microwave ablation and received no more than 16 cycles of Camrelizumab

Microwave ablation

Microwave ablation

Group Type: OTHER

Microwave ablation

Intervention Type: DEVICE

Tumor received treatment of microwave ablation

Interventions

Microwave ablation plus Camrelizumab

Tumor received treatment of microwave ablation and received no more than 16 cycles of Camrelizumab

Intervention Type: COMBINATION_PRODUCT

Microwave ablation

Tumor received treatment of microwave ablation

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

1. 18～79 years old;

2. Multiple pulmonary nodules diagnosed by CT, the number of target lesions ≥2 and ≤5 (definition of target lesions: the largest diameter of a single nodule ≥8 mm or the largest diameter of a solid component ≥5mm, and the largest single nodule Diameter ≤30 mm), the target lesions are distributed in at least two lung lobes;

3. The target lesions need to be pathologically indicated as lung cancer, and at least one of the target lesions is pathologically diagnosed as lung cancer (at least one target lesion is pathologically diagnosed as lung cancer, and the CT follow-up after anti-inflammatory treatment for the remaining target lesions is clear and stable for no less than 3 months, which is also consistent with the entry Group conditions);

4. The patient has no lymph node metastasis, lung metastasis or distant organ metastasis (N0, M0);

5. ECOG PS score 0-2;

6. Expected survival time ≥ 12 months;

7. Sufficient hematology function, defined as absolute neutrophil count ≥1.5×109/L, platelet count ≥80×109/L, hemoglobin ≥90g/L (no history of blood transfusion within 7 days, no G-CSF and others Correction of hematopoietic stimulating factors);

8. Sufficient liver function, defined as all patients with total bilirubin level ≤1.5 times upper limit of normal (ULN) and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels ≤2.5 times ULN;

9. Sufficient renal function, defined as creatinine clearance ≥50ml/min (Cockcroft-Gault formula);

10. The coagulation function is adequate, defined as the international normalized ratio (INR) or prothrombin time (PT) ≤ 1.5 times ULN; if the subject is receiving anticoagulation therapy, as long as the INR/PT is within the proposed range of anticoagulation drugs Can;

11. For female subjects of childbearing age, the urine or serum pregnancy test should be negative within 3 days before receiving the first study drug administration. If the urine pregnancy test result cannot be confirmed as negative, a blood pregnancy test is required;

12. If there is a risk of conception, male and female patients need to use high-efficiency contraception (that is, a method with a failure rate of less than 1% per year) and continue until at least 180 days after stopping the trial treatment;

13. Subjects voluntarily join the study and sign written informed consent before any trial-related procedures are implemented. They have good compliance and cooperate with follow-up.

Exclusion Criteria

1. Genetic testing is positive for at least one mutation of EGFR, ALK, ROS1 fusion, BRAF V600E mutation, and NTRK fusion;

2. Pulmonary nodules with the largest diameter> 30mm in preoperative imaging examination;

3. Preoperative imaging examination or mediastinal lymph node puncture indicates patients with positive preoperative lymph nodes;

4. Patients with distant metastasis or chest or ascites found in preoperative examination;

5. Currently participating in interventional clinical research treatment, or receiving treatment with other research drugs or research devices within 3 months before the first intervention;

6. Any systemic anti-tumor treatment before tumor ablation, including interventional chemoembolization, radiotherapy, chemotherapy, targeted therapy, or Chinese patent medicine with anti-tumor indications or immunomodulatory drugs (thymosin, interferon, interleukin, etc.) ), or received major surgery within 3 weeks before the first intervention;

7. Have received the following therapies in the past: anti-PD-1, anti-PD-L1 or anti-PD-L2 drugs or drugs that stimulate or synergistically inhibit T cell receptors (for example, CTLA4, OX-40, CD137);

8. There are multiple factors that affect surgery or ablation (such as coagulation dysfunction, immune system disease, etc.);

9. Abnormal coagulation function (PT>16 s, APTT>43 s, TT>21 s, Fbg< 2 g/L), bleeding tendency (such as active peptic ulcer) or receiving thrombolytic or anticoagulant therapy;

10. Pulmonary hemorrhage ≥ CTCAE grade 2 occurred within 4 weeks before the first intervention; other parts of hemorrhage ≥ CTCAE grade 3 occurred within 4 weeks before treatment;

11. Known history of human immunodeficiency virus (HIV) infection (ie HIV 1/2 antibody positive), known syphilis infection (syphilis antibody positive), active tuberculosis, active hepatitis without treatment;

12. People with severe impairment of heart, liver, and kidney functions (heart function grades 3 to 4, ALT and/or AST are more than 3 times the upper limit of normal, and Cr exceeds the upper limit of normal);

13. Known mental illness or drug abuse that may affect compliance with test requirements;

14. Patients with other malignant tumors or hematological diseases;

15. Pregnant, planned pregnancy and breast-feeding female patients (when urine HCG>2500IU/L, it is diagnosed as early pregnancy);

16. The investigator believes that it is not suitable for inclusion.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 79 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shanghai Pulmonary Hospital, Shanghai, China

OTHER

Sponsor Role: lead

Responsible Party

Chang Chen

Shanghai Pulmonary Hospital

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Chang Chen, Dr

Role: STUDY_CHAIR

Shanghai Pulmonary Hospital, Shanghai, China

Locations

Changhai Hospital

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Shanghai First People's Hospital

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Ruijin Hospital

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Shanghai Tenth People's Hospital

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Renji Hospital

Shanghai, Shangh, China

Site Status: RECRUITING

Countries

China

Central Contacts

Chang Chen, Dr

Role: CONTACT

2031222@tongji.edu.cn

65115006 ext. 021

Facility Contacts

Chong Bai, Dr

Role: primary

Zheng Ruan

Role: primary

Chang Chen, MD, PhD

Role: primary

chenthoracic@163.com

+86-021-65115006 ext. 2074

Wei Chen

Role: primary

Chuanwu Cao

Role: primary

Jiachang Chi

Role: primary

Other Identifiers

L20-349

Identifier Type: -

Identifier Source: org_study_id