A Study of Camrelizumab Plus Apatinib as Consolidation Therapy in Non-Small Cell Lung Cancer Patients Treated With Chemoradiotherapy

NCT ID: NCT04749394

Last Updated: 2022-08-16

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 42 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-03-17
• Study Completion Date: 2025-06-30

Brief Summary

This is a phase II, open-Label, multi-centre study to determine the efficacy and safety of Camrelizumab plus apatinib in participants with unresectable Stage III Non-Small Cell Lung Cancer (NSCLC), who have not progressed following platinum-based concurrent chemoradiation therapy (cCRT) or sequential chemoradiation therapy (sCRT). This study will be conducted in China mainland.

Detailed Description

This trial will evaluate the efficacy and safety of camrelizumab plus apatinib in participants with unresectable stage III NSCLC who have not progressed following definitive, platinum-based cCRT or sCRT. The primary endpoint is progression free survival (PFS) in the intent-to-treat (ITT) population. The secondary endpoints are as follows: 1) Overall survival (OS); 2) 1, 2, 3-year OS rates; 3) PFS rates at 12-monthand 18-month; 4) Objective response rate (ORR), 5) Duration of response (DoR); 6) Time to death or distant metastasis (TTDM); 7) Adverse effects (AEs) and severe adverse effects (SAEs) ;8) Quality of life (QoL).Exploratory objective is to explore potential biomarkers associated with efficacy.

Conditions

Locally Advanced Non-Small Cell Lung Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Experimental Arm

Camrelizumab plus apatinib as consolidation therapy

Group Type: EXPERIMENTAL

Camrelizumab, PD-1 monoclonal antibody

Intervention Type: DRUG

Camrelizumab 200mg IV, Q3W, until clinical progression/deterioration or confirmed radiological progression, or up to 1 year.

Apatinib, VEGFR2 antibody

Intervention Type: DRUG

Apatinib 250mg PO, QD, until clinical progression/deterioration or confirmed radiological progression, or up to 1 year.

Interventions

Camrelizumab, PD-1 monoclonal antibody

Camrelizumab 200mg IV, Q3W, until clinical progression/deterioration or confirmed radiological progression, or up to 1 year.

Intervention Type: DRUG

Apatinib, VEGFR2 antibody

Apatinib 250mg PO, QD, until clinical progression/deterioration or confirmed radiological progression, or up to 1 year.

Intervention Type: DRUG

Other Intervention Names

SHR-1210; Apatinib Mesylate

Eligibility Criteria

Inclusion Criteria

1. Patients aged ≥18 years, male and female are not limited;

2. Patients with ECOG score of 0-1;

3. Life expectancy ≥12 weeks;

4. Patients must have histologically or cytologicallyproved NSCLC, and present with locally advanced, unresectable Stage III disease(according to 8th AJCC/UICC Classification);

5. Receipt of concurrent or sequential chemoradiation therapy which must have been completed within 42 days prior to first dose administration of the study; Consolidation chemotherapy is not permitted.

6. No progression following definitive, platinum-based, concurrent or sequential chemoradiation therapy;

7. Subject with prior anti-cancer treatment can only be enrolled when all toxicities of prior anti-cancer treatment has recovered to baseline or ≤ Grade 1, except for hearing loss, alopecia and fatigue. (according to National Cancer Institute [NCI] Common Terminology Criteria for Adverse Events [CTCAE] V5.0);

8. No prior exposure to any anti-CTLA-4, anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-VEGF treatments, as well as therapeutic anticancer vaccines;

9. Agreement to provide tumor histological specimens required for this study;

10. Adequate organ and marrow function required;

11. Fertile female were required to have a negative serum or urine pregnancy test within 72 days before the start dose of study medication; If female of childbearing potential, is willing to use adequate contraception for the course of the study through 90 days after the last dose of study medication; if male with a female partner(s) of child-bearing potential, he must agree to use adequate contraception starting with the first dose of study medication through 90 days after the last dose of study medication or have been surgically sterilized;

12. Provision of signed ICF.

Exclusion Criteria

1. Mixed small cell lung cancer histology;

2. Disease progression after concurrent/sequential chemoradiotherapy;

3. Major surgical procedure (as defined by the Investigator) within 28 days prior to the first dose of treatment;

4. Receipt of live attenuated vaccine within 28 days prior to the first dose of treatment;

5. Previous enrolment of another study and receiving any study drug within 28 days prior to the first dose of treatment;

6. Patients with ≥Grade 2 pneumonitis from the prior anti-cancerchemoradiation therapy;

7. Imaging (CT or MRI) shows the tumor invading large vessels or blurring the boundary with vessels;

8. History of organ transplant or allogeneic hematopoietic stem cell transplantation;

9. Patients with any active autoimmune disease or history of autoimmune disease;

10. Patients with innate or acquired immune deficiency, such as human immunodeficiency virus (HIV) infection;

11. Uuntreated active hepatitis B or, hepatitis C or active tuberculosis or currently receiving anti-tuberculosis treatment co-infection with hepatitis B and hepatitis C;

12. Subjects receiving systemic treatment with corticosteroids (>10mg/day of prednisone or its equivalent) or other immunosuppressants within 14 days prior to the first administration;

13. History of another primary malignancy within 5 years prior to enrollment, except for adequately treated basal or squamous cell carcinoma of the skin or cancer of the cervix in situ and the disease under study;

14. Pulmonary function test: FEV1< 1.2L or DLCO < 50% of predicted value;

15. Patients with cardiac insufficiencyheart diseases including: 1) NYHA III-IV; 2）Acute coronary syndrome; 3) Supraventricular or ventricular arrhythmias requiring clinical intervention; 4) Pericardial and myocardial diseases; 5) Echocardiography indicates that the left ventricular ejection fraction (LVEF) is < 50%;

16. Patients with uncontrollable hypertension (systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg, despite the best drug treatment);

17. Patients who have had arteriovenous thrombosis events within 6 months, such as cerebrovascular accident (including cerebral embolism, deep vein thrombosis, pulmonary embolismcerebral hemorrhage, cerebral infarction, transient ischemic attack, etc.);

18. Patients with hemoptysis, active bleeding, ulcer, intestinal perforation and intestinal obstruction within 3 months before administration;

19. Significant hemoptysis symptoms or daily amount of hemoptysis up to 2.5mL or more within 30 days before the first administration;

20. Known hereditary or acquired bleeding and thrombosis tendency (such as hemophilia, coagulation dysfunction, thrombocytopenia, hypersplenism, etc.);

21. Routine urine test indicated that urine protein was ≥ (++), or 24-hour urine protein was ≥ 1g, or severe liver and kidney dysfunction;

22. Patients with severe infection or fever of unknown origin > 38.5 degrees C within 24 weeks before medication;

23. Pregnant or lactating women; those with fertility who are unwilling or unable to take effective contraceptive measures;

24. Known allergies, hypersensitivity, or intolerance to camrelizumab or its excipients, apatinib and chemotherapy drugs;

25. Any conditions, judged by investigators, that may impair the subject or cause the subject to be unable to meet or perform the study requirements.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Chinese Academy of Medical Sciences

OTHER

Sponsor Role: lead

Responsible Party

Zhouguang Hui, M.D.

Chief physician, Director of VIP Department

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Beijing, , China

Site Status: RECRUITING

Countries

China

Central Contacts

Zhouguang Hui

Role: CONTACT

drhuizg@163.com

18611876792

Yirui Zhai

Role: CONTACT

januarywind@163.com

18610168510

Facility Contacts

Zhouguang Hui, M.D.

Role: primary

drhuizg@163.com

8610-87787230

Other Identifiers

NCC004692

Identifier Type: -

Identifier Source: org_study_id