Camrelizumab With Chemotherapy in Adults With Medically Inoperable Early Stage NSCLC

NCT ID: NCT04530227

Last Updated: 2020-11-13

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-09-25
• Study Completion Date: 2025-12-31

Brief Summary

The purpose of this study is to assess the efficacy and safety of Camrelizumab plus chemotherapy in the treatment of adult participants with medically inoperable Stage I or IIA non-small cell lung cancer (NSCLC).

Detailed Description

This trial will evaluate the safety and efficacy of camrelizumab in combination with chemotherapy, followed by camrelizumab alone after 4-6 cycles of combination in participants with medically inoperable stage I or IIA non-small cell lung cancer (NSCLC). The primary objective of this pilot study is to determine the Camrelizumab plus chemotherapy improves progression-free survival (PFS) . All the efficacy and safety are assessed by investigator : 1) response rate (ORR), 2) disease control rate (DCR); 3) overall survival (OS), 4) PFS rate of 1-year, 2-year, and 5-year; and 5) OS rate of 1-year, 2-year, and 5-year.

Explore objective is potential biomarker associated with efficacy.

Conditions

Early Stage Non-small Cell Lung Cancer

Keywords

programmed cell death 1 (PD-1, PD1); programmed cell death-ligand 1 (PD-L1, PDL1)

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Camrelizumab combined with chemotherapy

Participants receive camrelizumab 200 mg by intravenous (IV) infusion prior to chemotherapy on Day 1 of each 21-day cycle for up to 18 cycles PLUS Investigator's choice of chemotherapy.

Interventions:

Biological: Camrelizumab

Group Type: EXPERIMENTAL

Biological: Camrelizumab

Intervention Type: DRUG

PD-1

Pemetrexed

Intervention Type: DRUG

chemotherapy

Nab-paclitaxel

Intervention Type: DRUG

chemotherapy

Interventions

Biological: Camrelizumab

PD-1

Intervention Type: DRUG

Pemetrexed

chemotherapy

Intervention Type: DRUG

Nab-paclitaxel

chemotherapy

Intervention Type: DRUG

Other Intervention Names

SHR-1210; Pemetrexed Disodium; Paclitaxel for Injection（Albumin Bound）

Eligibility Criteria

Inclusion Criteria

1. Patients aged ≥18 years, male and female are not limited;

2. Patients with ECOG score of 0-1;

3. Life expectancy ≥12 weeks;

4. Patients must have histologically- or cytologically-documented NSCLC (according to 2015 WHO Classification);

5. Patients with stage I - IIA (T1-T2bN0M0, tumor size ≤ 50mm) confirmed by radiographic；and medical inoperable, unable to undergo thoracic surgery, or refusing to surgery (according to the eighth edition of TNM staging);

6. Patients with measurable target lesions according to the RECIST 1.1 standard;

7. Patients have not received prior treatment for their NSCLC, including radiotherapy, chemotherapy, surgery and target drugs;

8. Can provide tumor tissue;

9. Adequate organ and marrow function;

10. Fertile female were required to have a serum or urine pregnancy test within 72 hours before the start dose of study medication and the result has been negative;If female of childbearing potential, is willing to use adequate contraception for the course of the study through 90 days after the last dose of study medication; if male with a female partner(s) of child-bearing potential, must agree to use adequate contraception starting with the first dose of study medication through 90 days after the last dose of study medication;

11. Provision of signed ICF.

Exclusion Criteria

1. Known any distance metastases;

2. Patients with known EGFR gene mutation or ALK fusion mutation;

3. Patients with any active autoimmune disease or history of autoimmune disease;

4. Patients with innate or acquired immune deficiency, such as human immunodeficiency virus (HIV) infection, active hepatitis B, hepatitis C or co-infection with hepatitis B and hepatitis C;

5. Subjects requiring systemic treatment with corticosteroids (> 10 mg / day of prednisone or its equivalent) or other immunosuppressants within 14 days prior to the first administration;

6. Patient must not have received a live, attenuated vaccine within 4 weeks prior to the first administration;

7. Any therapy for NSCLC treatment;

8. Patients with other malignant tumors in the past 5 years;

9. Patients with previous or current pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiologic pneumonia, drug-induced pneumonia and active pneumonia confirmed by imaging;

10. Patients with cardiac insufficiency;

11. Routine urine test indicated that urine protein was >= (+ +), or 24-hour urine protein was >= 1g, or severe liver and kidney dysfunction;

12. Patients with severe infection or fever of unknown origin >38.5 ℃ within 4 weeks prior to the first administration;

13. Patients with known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation;

14. Pregnant or lactating women; those with fertility who are unwilling or unable to take effective contraceptive measures;

15. Known allergies, hypersensitivity, or intolerance to camrelizumab or its excipients or to pemetrexed or to nab-paclitaxel;

16. Any condition that, in the opinion of the investigator, would interfere with evaluation of the study drug or interpretation of patient safety or study results，or the patient is unlikely to comply with study procedures, restrictions, and requirements.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tianjin Medical University Cancer Institute and Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Tianjin Medical University Cancer Institute and Hospital

Tianjin, , China

Site Status: RECRUITING

Countries

China

Central Contacts

Changli Wang, PhD

Role: CONTACT

Phone: 86-22-23340123

Email: wangchangli@medmail.com.cn

Lianming Zhang, PhD

Role: CONTACT

Phone: 86-22-23340123

Facility Contacts

Changli Wang

Role: primary

Other Identifiers

MA-NSCLC-II-007

Identifier Type: -

Identifier Source: org_study_id