Phase Ⅱ Trial of Camrelizumab in Patients Without Distant Metastasis Nasopharyngeal Carcinoma

NCT ID: NCT04782765

Last Updated: 2021-03-04

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 59 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-03-20
• Study Completion Date: 2025-03-20

Brief Summary

To see the effect if a combination of neoadjuvant chemotherapy combined with Camrelizumab followed by chemoradiotherapy in treating patients without distant metastasis nasopharyngeal carcinoma

Detailed Description

The primary objective of this phase 2 study is to assess disease-free survival rate of 3 years in patients with NPC. The secondary objective is to observe objective response rate, progression free survival, overall survival and safety

Conditions

Disease-free Survival Rate

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Camrelizumab+Chemotherapy+Chemoradiotherapy

Patients received neoadjuvant Camrelizumab 200mg combined with chemotherapy (Cisplatin 20mg/m2, Day 1-3, Docetaxel 75mg/m2, Day 1) for 2 cycles every 21 days, followed by concurrent chemoradiotherapy with Camrelizumab monotherapy maintenance

Group Type: EXPERIMENTAL

Camrelizumab+Chemotherapy+Chemoradiotherapy

Intervention Type: DRUG

Patients received neoadjuvant Camrelizumab 200mg combined with chemotherapy (Cisplatin 20mg/m2, Day 1-3, Docetaxel 75mg/m2, Day 1) for 2 cycles every 21 days, followed by concurrent chemoradiotherapy with Camrelizumab monotherapy maintenance

Interventions

Camrelizumab+Chemotherapy+Chemoradiotherapy

Patients received neoadjuvant Camrelizumab 200mg combined with chemotherapy (Cisplatin 20mg/m2, Day 1-3, Docetaxel 75mg/m2, Day 1) for 2 cycles every 21 days, followed by concurrent chemoradiotherapy with Camrelizumab monotherapy maintenance

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Sign written informed consent before enrollment;
• Male or female under the age of 70;
• Diagnosed by imaging examination and histopathologic examination Ⅱ I - Ⅳ b period in patients with nasopharyngeal carcinoma
• No first-line treatment has been received
• ECOG/PS score: 0 ~ 1;
• Expected survival is greater than 12 weeks;
• The function of vital organs meets the following requirements (excluding the use of any blood components and cell growth factors within 14 days) :

1. Routine blood examination (no blood transfusion or use of hematopoietic stimulant subclass drugs to correct within 14 days before screening) Hemoglobin (Hb) ≥90 g/L; Absolute neutrophil count (ANC) ≥1.5×109/L; Absolute value of lymphocyte count (LC) ≥0.5×109/L; Platelet count (PLT) ≥100×109/L; White blood cell count (WBC) ≥4.0×109/L and ≤15×109/L;

2. Biochemistry (no blood transfusion or albumin within 14 days prior to screening) AST and ALT ≤2.5 x ULN ALP ≤ 2.5 x ULN TBiL≤ 1.5 x ULN ALB≥30 g/L; Cr≤1.5×ULN, and creatinine clearance rate (CrCl)≥80 mL/min (Cockcroft-Gault formula)

• Normal coagulation function, no active bleeding and thrombotic disease A. International standardized ratio INR≤1.5×ULN; B. Partial thromboplastin time APTT≤1.5×ULN; C. Prothrombin time Pt ≤1.5×ULN;
• For women of non-surgical sterilization or reproductive age, use of a medically approved contraceptive method (such as intrauterine device, birth control pills or condoms) during the study treatment period and within 3 months after the end of the study treatment period;Women of reproductive age who are not surgically sterilized must be negative for serum or urine HCG within 7 days prior to study enrolment;And must be non-lactation;Male patients who are not surgically sterilized or of reproductive age need to agree to use a medically approved method of contraception with their spouse for the duration of the study treatment period and for three months after the end of the study treatment period.
• Subjects volunteered to participate in this study, with good compliance, safety and survival follow-up.

• Live vaccine was administered less than 4 weeks before or possibly during the study period;
• Subject has a known history of psychotropic substance abuse, alcohol abuse or drug abuse;
• Subjects received traditional Chinese medicine treatment within 4 weeks before the first treatment;
• Subject is unable or does not agree to bear the cost of examination and treatment at their own expense, except for clinical investigational drugs, combined chemotherapy and SAE related to clinical investigational drugs combined chemotherapy;
• Researchers think that should be left out in this study, the researchers determine, for example, the subjects have other factors that may result in this study were forced to midway termination, such as, other serious disease (including mental illness) need to merge treatment, there are serious abnormal laboratory examination, accompanied by factors such as family or society, will affect the safety of the subjects, or information and the collection of the sample.

Exclusion Criteria

• Previous radiation, chemotherapy, hormone therapy, surgery, or molecular targeted therapy;
• Imaging confirmed patients with distant metastasis;
• Subjects have previous or co-existing malignancies (except cured basal cell carcinoma of the skin and carcinoma in situ of the cervix);
• Previous treatment with carrelizumab or other PD-1/PD-L1 inhibitors was not included;Subject is known to have a prior allergy to macromolecular protein formulations or to any of the carrizumab or chemotherapy ingredients used by the subject during neoadjuvant therapy;
• there is no active participants autoimmune disease or a history of autoimmune diseases (such as the following, but not limited to: autoimmune hepatitis, interstitial pneumonia, uveitis, enteritis, hepatitis, the pituitary gland inflammation, vasculitis, nephritis, thyroid function, thyroid function is reduced, always had thyroid surgery must be incorporated into;Subjects with vitiligo or asthma that had been in complete remission during childhood were enrolled as adults without any intervention;Asthmatic subjects requiring bronchodilators for medical intervention were not included);
• Subjects are using immunosuppressants and continue to use them within 2 weeks before enrolment;
• Patients with clinical cardiac symptoms or diseases that are not well controlled, such as :(1) NYHA2 heart failure or above, (2) unstable angina, (3) myocardial infarction within 1 year, (4) clinically significant supraventricular or ventricular arrhythmias requiring treatment or intervention;
• Abnormal coagulation function (PT>16 s, APTT>43S, TT>21 s, Fbg>2g/L) with bleeding tendency or undergoing thrombolytic or anticoagulant therapy;
• Previous or current severe bleeding (bleeding within 3 months >30 ml), hemoptysis (within 4 weeks >5 ml fresh blood) or thromboembolic events (including stroke events and/or transient ischemic attack) within 12 months;
• Subjects were still using TCM immunomodulator 2 weeks before enrollment;
• Subjects have active infection or unexplained fever during screening or prior to first administration >38.5 degrees (subject fever due to tumor can be included, as determined by the investigator);
• Patients with previous and current objective evidence of pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonia, drug-related pneumonia, severe pulmonary function impairment, etc.;Subjects who still had grade ≥2 peripheral neuropathy within 3 days before the first medication;

• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tianjin Medical University Cancer Institute and Hospital

OTHER

Sponsor Role: lead

Responsible Party

Peiguo Wang

Chief Physician

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Peiguo Wang

Tianjin, Tianjin Municipality, China

Site Status: RECRUITING

Countries

China

Facility Contacts

Peiguo Wang, doctor

Role: primary

18526812877@163.com

18622221196

Ruijun Kang

Role: backup

hrkangruijun@163.com

18360697909

References

Wang Z, Sun Y, Wang Q, Chai Y, Sun J, Zhang X, Wang Q, Wang W, Wang P. Induction chemotherapy plus camrelizumab combined with concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma in non-endemic areas: a phase 2 clinical trial in North China. BMC Med. 2025 Feb 27;23(1):126. doi: 10.1186/s12916-025-03964-9.

Reference Type: DERIVED

PMID: 40016735 (View on PubMed)

Other Identifiers

OBU-TJ-CC-HNC-II-002

Identifier Type: -

Identifier Source: org_study_id