SBRT for Oligoprogressive NSCLC After First Line Treatment With Immune Checkpoint Inhibitors

NCT ID: NCT05387044

Last Updated: 2022-05-24

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 28 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-05-01
• Study Completion Date: 2024-04-30

Brief Summary

The treatment modality with immunotherapy has been the first-line standard treatment for advanced NSCLC. But more than 2/3 patients still develop acquired drug resistance within 5 years of immunotherapy, and more than 1/2 patients are oligoprogressive. Stereotactic body radiation therapy (SBRT) plays a growing role in the management of oligometastatic disease. This study aims to evaluate the efficacy and safety of SBRT for oligoprogressive NSCLC after first line treatment with immune checkpoint inhibitors.

Conditions

NSCLC Stage IV

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

SBRT

Patients with oligoprogressive NSCLC after first line treatment with immune checkpoint inhibitors will be treated with SBRT for all progressing lesions.

Group Type: EXPERIMENTAL

SBRT

Intervention Type: RADIATION

Patients with oligoprogressive NSCLC after first line treatment with immune checkpoint inhibitors will be treated with SBRT for all progressing lesions.

Interventions

SBRT

Patients with oligoprogressive NSCLC after first line treatment with immune checkpoint inhibitors will be treated with SBRT for all progressing lesions.

Intervention Type: RADIATION

Eligibility Criteria

Inclusion Criteria

• Age at least 18 years;
• ECOG PS 0-1;
• Patients with pathologically confirmed stage IV NSCLC by tumor biopsy and/or fine-needle aspiration （AJCC the 8th Edition）;
• Stable Disease for at least 6 months after first line immunotherapy;
• Oligoprogressive disease in 5 or fewer lesions and 3 or fewer organs;
• All oligopreogressive lesion ≤ 5cm, and intracranial lesion ≤3cm or 30cc;
• Progressive disease would be amenable to SBRT and without indications for palliative radiotherapy in the opinion of the investigator;
• Patients with a history of radiotherapy are eligible if radiotherapy administered more than 4 weeks before study entry;
• Adequate organ function prior to enrollment:

Adequate bone marrow function: white blood cell (WBC) count ≥ 3.0 * 10 ^ 9/L or neutrophil count ≥ 1.5 * 10 ^ 9/L, platelet count ≥ 100 * 10 ^ 9/L and hemoglobin ≥90g/L,; Adequate hepatic function: total bilirubin, urea nitrogen and serum creatinine≤ 1.5 x upper limit of normal (ULN). Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) ≤2.0 ULN;

• Life expectancy of more than 3 months;
• Ability to understand and willingness to provide the informed consent and signed informed consent for the use of fresh tumor biopsies before and during the treatment;
• Women of childbearing age and men must agree to use effective contraception during the trial.

Exclusion Criteria

• History of another malignancy or concurrent malignancy (except for cured non-melanoma skin cancer, low-risk prostate cancer, T1/T2 glottic cancer, stage 0 or I breast cancer, non-invasive bladder cancer, cervical cancer in situ);
• Positive for driver genes including EGFR, ALK, and ROS-1;
• Mixed small cell with non-small cell lung cancer histology;
• Malignant pleural or ascites;
• Patients with brain metastasis require intracranial decompression;
• Symptoms of spinal cord compression;
• Severe autoimmune disease: inflammatory bowel disease (including Crohn's disease and ulcerative colitis), rheumatoid arthritis, scleroderma, systemic lupus erythematosus, Wegener's granulomatosis and related vasculitides;
• Symptomatic interstitial lung disease or clinically active infectious/non-infectious pneumonitis.
• History of another malignancy or concurrent malignancy;
• Active infection, congestive heart failure, or any evidence of myocardial infarction, unstable angina pectoris or cardiac arrhythmia within 6 months prior to enrollment;
• The patient is pregnant (confirmed by serum b-HCG if applicable) or is breastfeeding;
• Mental disorders, drug abuse, and social condition that may negatively impact compliance in the investigator's opinion.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Zhejiang Cancer Hospital

OTHER

Sponsor Role: lead

Responsible Party

Xiaojing Lai

Clinical Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Xiaojing Lai

Role: PRINCIPAL_INVESTIGATOR

Department of Thoracic Radiotherapy, Zhejiang Cancer Hospital

Locations

Zhejiang Cancer Hospital

Hangzhou, Zhejiang, China

Site Status: RECRUITING

Countries

China

Central Contacts

Xiaojing Lai

Role: CONTACT

laixj@zjcc.org.cn

13819480002

Min Fang, MD

Role: CONTACT

fangmin@zjcc.org.cn

13738152645

Facility Contacts

Xiaojing Lai

Role: primary

laixj@zjcc.org.cn

13819480002

Min Fang, MD

Role: backup

fangmin@zjcc.org.cn

13738152645

Other Identifiers

2022-OligoSBRT-IIT

Identifier Type: -

Identifier Source: org_study_id