Local Radiotherapy in Combination With Immunotherapy in Advanced Solid Tumors Patients

NCT ID: NCT05097781

Last Updated: 2021-10-28

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 55 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-03-21
• Study Completion Date: 2024-09-30

Brief Summary

This is a phase II study to observe efficacy of combining local radiotherapy with PD-1blockade in patients with advanced solid tumors. All patients will accept at least one site of radiotherapy together with PD-1 blockade. The study will evaluate changes of unirradiated and irradiated lesions.

Conditions

Solid Tumor

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Treatment arm

Local irradiation + immunotherapy

Group Type: EXPERIMENTAL

PD-1 blocking antibody

Intervention Type: DRUG

All patients with more than one distant metastatic lesions will accept at least one site of radiotherapy and PD-1 blockade at the same time.

Interventions

PD-1 blocking antibody

All patients with more than one distant metastatic lesions will accept at least one site of radiotherapy and PD-1 blockade at the same time.

Intervention Type: DRUG

Other Intervention Names

irradiation

Eligibility Criteria

Inclusion Criteria

1. Adult patients 18-75 years old with the right to make medical decisions

2. Signed informed consent form

3. ECOG score of 0-2

4. Clear pathological diagnosis of the primary site

5. Multiple distant metastases

6. Stable assessment of brain metastases after treatment can be enrolled (more than 6 weeks)

7. Bone metastases combined with soft tissue mass formation can be enrolled

8. imaging with ≥ 2 clearly assessable lesions (bone metastases alone without soft tissue mass formation, brain metastases not as target lesions)

9. expected survival ≥ 6 months

10. Progression after ≥ 1 prior line of therapy regimen with no standard treatment regimen or intolerable toxicities, including all three of the following:

1. Patients must have failed to respond to at least one prior standard of care regimen

2. The patient must not have a conventional treatment option that is clinically proven to provide long-term control of the disease and the patient refuses other conventional treatment options

3. The patient is intolerant to the toxic side effects of the standard treatment regimen

11. No prior immunotherapy history

12. Time to last systemic therapy (including monoclonal antibodies) ≥ 4 weeks

13. Previous radiotherapy to non-target sites with other evaluable lesions can be enrolled

14. Laboratory examination indexes meet the following requirements: WBC ≥ 3×109/L, ANC ≥ 2.0×109/L, PLT ≥ 80×109/L, Hb ≥ 80g/L (according to the normal standards of the central laboratory department); liver function: total bilirubin, ALT and AST are ≤ 1.5xUNL (upper limit of normal value); AST (SGOT)/ALT (SGPT) ≤ 2.5xUNL (upper limit of normal value) ALT (SGPT) ≤ 2.5 x IULN (upper limit of normal value); renal function: Cr≦1.5xUNL (upper limit of normal value), and creatinine clearance rate≧60ml/min; thyroid function T3, T4 within normal range (hypothyroidism can be supplemented with oral thyroxine); cardiac function: cardiac protein three and pro-BNP within normal range, no previous Adrenal function: normal cortisol secretion function or correctable by endocrine assessment

15. HBV infected patients with HBV-DNA copy number less than 500 IU/ml

16. No history of other malignancies within 5 years (except skin basal cell carcinoma)

Exclusion Criteria

1. Uncontrolled brain metastases (stabilization time <6 weeks)

2. Bone metastases alone without clear soft tissue mass formation

3. Bone marrow infiltration

4. Presence of clinical factors (e.g., bleeding, active infection, or psychiatric factors) that the investigator determines may interfere with the completion of the study process

5. Inability to administer radiotherapy due to organ-threatening or other factors as assessed by the investigator

6. Patients requiring long-term maintenance steroid therapy (including oral, intravenous use); topical use or inhalation may be included in the study

8. history of active tuberculosis or non-infectious pneumonia or any clinical evidence

9. Active viral hepatitis with HBV DNA > 500 IU/ml

10. Immunodeficiency syndrome

11. comorbid serious medical disorders with concomitant diseases or conditions affecting the normal enrollment of the patient or safety during the study

12. previous immunotherapy for other tumors

13. History of other malignancies within 5 years (except cured basal cell carcinoma of the skin);

14. Pregnant or lactating women;

15. Unable or unwilling to sign the informed consent form.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ruijin Hospital

OTHER

Sponsor Role: lead

Responsible Party

Jiayi Chen

Chief of Department of Radiation Oncology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jiayi Chen, MD

Role: PRINCIPAL_INVESTIGATOR

Ruijin Hospital

Locations

Ruijin Hospital, Shanghai Jiaotong University School of Medicine

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Yujie Wang, MD

Role: CONTACT

Phone: 8602164370045

Email: wyj12054@rjh.com.cn

Yunsheng Gao, MD

Role: CONTACT

Email: gys11856@rjh.com.cn

Facility Contacts

Jiayi Chen, MD

Role: primary

Other Identifiers

RuijinHDR

Identifier Type: -

Identifier Source: org_study_id