Impact of Vitamine D Status on in Vitro Fertilization Outcomes

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-01

Study Completion Date

2016-01-01

Brief Summary

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Non skeletal effect of vitamin D have been the focus of much interest in the past decade. During the last years, special attention has been given to the impact of vitamin D on human reproduction. Its receptor is expressed in most reproductive organs including hypothalamus, pituitary gland, uterus, ovary, mammary gland and the placenta. In vitro experiments suggest that vitamin D would be involved in regulated embryo-implantation. Concerning AMH, vitamin D seems to alters AMH signaling in human granulosa cells although their circulated levels are correlated in lated reproductive aged women. The results of precedents studies about the impact of vitamin D on IVF outcomes remain conflicting The aim of our study was to assess in a large unselected population of infertile women, the impact of vitamin D deficiency on IVF outcome and to examine the relationship between serum vitamin D levels and the ovarian reserve marker AMH.

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Detailed Description

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Vitamin D was measured on the sixth day of stimulation. According to vitamin D level, women were divided into 2 groups (deficiency when 25(OH)D \<20 ng/ml and sufficient when 25(OH)D \>20 ng/ml).

Pregnancy rates were compared among these two groups after controlling age, BMI, characteristics of ovarian stimulation, number of ovocytes obtains, etc.

Conditions

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Infertility

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Normal

Women with sufficient vitamin D level, when 25(OH)D \>20 ng/ml

vitamin D estimation

Intervention Type BIOLOGICAL

Serum samples to estimate vitamin D status were collected on the sixth day of stimulation

Deficient

women deficiency vitamin D level, when 25(OH)D \<20 ng/ml

vitamin D estimation

Intervention Type BIOLOGICAL

Serum samples to estimate vitamin D status were collected on the sixth day of stimulation

Interventions

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vitamin D estimation

Serum samples to estimate vitamin D status were collected on the sixth day of stimulation

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing IVF/ICSI in the center of medical assistance for the procreation of the french hospital of Nantes between september 2010 and may 2011.