The Effect of Vitamin D on in Vitro Fertilization Outcome
NCT ID: NCT02361827
Last Updated: 2025-03-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
688 participants
OBSERVATIONAL
2018-01-01
2024-12-01
Brief Summary
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Detailed Description
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Ongoing pregnancy rate are compared among these three groups after controlling age, number of embryos transferred, ect.
In addition, Vitamin D level is also meassured before embryo transfer in FET cycles with PGT treatment. The effect of Vitamin D on IVF outcome is detected in patients transferred with Euploid embryos.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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A1, Vitamin D deficient
Vitamin D level before cycle \< 20 ng/mL.
Embryo transfer
For patients in each group after oocyte retrieval, they will have embryo transferred 3 or 5 days after oocyte retrieval. For FET cycles, they will have ET with an euploid blastocyst.
B1, Vitamin D insufficient
Vitamin D level before cycle 20-29.9 ng/mL
Embryo transfer
For patients in each group after oocyte retrieval, they will have embryo transferred 3 or 5 days after oocyte retrieval. For FET cycles, they will have ET with an euploid blastocyst.
C1, Vitamin D replete
Vitamin D level before cycle \> 30 ng/mL
Embryo transfer
For patients in each group after oocyte retrieval, they will have embryo transferred 3 or 5 days after oocyte retrieval. For FET cycles, they will have ET with an euploid blastocyst.
A2, Vitamin D deficient
Vitamin D level before ET \< 20 ng/mL (FET with Euploid embryos)
Embryo transfer
For patients in each group after oocyte retrieval, they will have embryo transferred 3 or 5 days after oocyte retrieval. For FET cycles, they will have ET with an euploid blastocyst.
B2, Vitamin D insufficient
Vitamin D level before ET 20-29.9 ng/mL (FET with Euploid embryos)
Embryo transfer
For patients in each group after oocyte retrieval, they will have embryo transferred 3 or 5 days after oocyte retrieval. For FET cycles, they will have ET with an euploid blastocyst.
C2, Vitamin D replete
Vitamin D level before ET \> 30 ng/mL (FET with Euploid embryos)
Embryo transfer
For patients in each group after oocyte retrieval, they will have embryo transferred 3 or 5 days after oocyte retrieval. For FET cycles, they will have ET with an euploid blastocyst.
Interventions
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Embryo transfer
For patients in each group after oocyte retrieval, they will have embryo transferred 3 or 5 days after oocyte retrieval. For FET cycles, they will have ET with an euploid blastocyst.
Eligibility Criteria
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Inclusion Criteria
2. basal FSH hormone level less than 10 mIU/mL
3. the first cycle of IVF treatment with standard long protocol
4. both ovarian present and normal uterus.
Exclusion Criteria
2. Gametes donation cycles
21 Years
40 Years
FEMALE
No
Sponsors
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Luoyang maternal and child hospital
UNKNOWN
The First Affiliated Hospital of Zhengzhou University
OTHER
Responsible Party
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Yingpu Sun
Director of Reproductive Medicine Center
Principal Investigators
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Zhiqin Bu, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University
Locations
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Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Countries
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References
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Wang K, Dong F, Ma S, Bu Z. The association between Vitamin D deficiency and clinical pregnancy rate in IVF patients with different age. Front Endocrinol (Lausanne). 2025 Jan 3;15:1485238. doi: 10.3389/fendo.2024.1485238. eCollection 2024.
Franasiak JM, Molinaro TA, Dubell EK, Scott KL, Ruiz AR, Forman EJ, Werner MD, Hong KH, Scott RT Jr. Vitamin D levels do not affect IVF outcomes following the transfer of euploid blastocysts. Am J Obstet Gynecol. 2015 Mar;212(3):315.e1-6. doi: 10.1016/j.ajog.2014.09.029. Epub 2014 Oct 11.
Fabris A, Pacheco A, Cruz M, Puente JM, Fatemi H, Garcia-Velasco JA. Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients. Fertil Steril. 2014 Dec;102(6):1608-12. doi: 10.1016/j.fertnstert.2014.08.030. Epub 2014 Sep 23.
Paffoni A, Ferrari S, Vigano P, Pagliardini L, Papaleo E, Candiani M, Tirelli A, Fedele L, Somigliana E. Vitamin D deficiency and infertility: insights from in vitro fertilization cycles. J Clin Endocrinol Metab. 2014 Nov;99(11):E2372-6. doi: 10.1210/jc.2014-1802. Epub 2014 Aug 14.
Rudick BJ, Ingles SA, Chung K, Stanczyk FZ, Paulson RJ, Bendikson KA. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril. 2014 Feb;101(2):447-52. doi: 10.1016/j.fertnstert.2013.10.008. Epub 2013 Nov 5.
Other Identifiers
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RMCZZU-Vitamin D
Identifier Type: -
Identifier Source: org_study_id
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