miRNA in Sweat, a Novel Digital Biomarker for Detection of Active Tuberculosis (TB)
NCT ID: NCT05048381
Last Updated: 2023-11-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
OBSERVATIONAL
2021-09-06
2022-10-31
Brief Summary
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The primary goal of this analysis is to define, for the first time, an miRNA fingerprint for tuberculosis in sweat. Samples that were collected as part of the Sweatb Study (NCT03667742) project are examined for the occurrence of disease-specific, non-coding miRNAs to define new biomarkers in the sweat. These biomarkers can be detected non-invasively and will help in the detection of patients with active tuberculosis.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Interventions
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Next Generation Sequencing
Next Generation Sequencing of sweat and whole blood samples for non-coding miRNAs to define biomarkers that enable to differentiate between patients with active tuberculosis, a differential diagnostic disease and healthy individuals.
Eligibility Criteria
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Inclusion Criteria
* Ability to understand the purpose of the study, provide signed and dated informed consent by patient or his/her legal representative
* In-patients with acute tuberculosis, suspected tuberculosis or other pulmonary diseases (pneumonia, Bronchitis, COPD)
* negative for Quantiferon- TB Gold Plus Test or ELISpot
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Fachhochschule Nordwestschweiz
OTHER
University Hospital, Basel, Switzerland
OTHER
Responsible Party
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Principal Investigators
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Jens Eckstein, Prof. Dr. med.
Role: PRINCIPAL_INVESTIGATOR
Chief Medical Information Office (CMIO), University Hospital Basel
Other Identifiers
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2021-01810; am21Eckstein2
Identifier Type: -
Identifier Source: org_study_id
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