GPC3 Targeted Fluorescence Image Guided Surgery of Hepatocellular Carcinoma
NCT ID: NCT05047510
Last Updated: 2023-08-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2021-09-10
2026-12-31
Brief Summary
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The main purposes of this study include:
① To raise the detection rate of hepatocellular carcinoma intraoperatively using the novel NIR-II fluorescence molecular imaging and the GPC-3 targeted fluorophore.
② To validate the safety and effectiveness of the designed GPC-3 targeted fluorophore for clinical application.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Anti-GPC3-IRDye800CW Intraoperative Fluorescence
The patients will receive an injection of fluorophore (Anti-GPC3-IRDye800CW) before the surgery. Then intraoperative fluorescence imaging will be performed to guide lesion resection.
Anti-GPC3-IRDye800CW
Drug Injection: Anti-GPC3-IRDye800CW
Interventions
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Anti-GPC3-IRDye800CW
Drug Injection: Anti-GPC3-IRDye800CW
Eligibility Criteria
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Inclusion Criteria
2. Planned to receive hepatectomy.
3. Liver function Child-Pugh A/B.
4. GPC-3 was validated highly expressed preoperatively.
5. Aged 18 to 75, and the expected lifetime is longer than 6 months.
6. Approved to sign the informed consent.
Exclusion Criteria
2. Enrolled in other trials in the past 3 months.
3. Another malignant tumor was found.
4. Undesirable function of heart, lung, kidney, or any other organs.
5. Unable to tolerate a hepatectomy.
6. The researchers considered inappropriate to be included.
18 Years
75 Years
ALL
Yes
Sponsors
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Chinese Academy of Sciences
OTHER_GOV
Responsible Party
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Zeyu Zhang, PHD
Principal Investigator
Locations
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Zhuhai People's Hospital
Zhuhai, Guangdong, China
The Affiliated Hospital of Southwest Medical University
Luzhou, Sichuan, China
Countries
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Central Contacts
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Other Identifiers
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Chinese Academy of Sciences
Identifier Type: -
Identifier Source: org_study_id
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