ITGA6 Targeting NIR-II Fluorescence Image Guided Surgery
NCT ID: NCT06204835
Last Updated: 2024-05-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE1
90 participants
INTERVENTIONAL
2024-01-07
2039-12-31
Brief Summary
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The main purposes of this study include:
1. To raise the detection rate of hepatocellular carcinoma intraoperatively using the novel NIR-II fluorescence molecular imaging and the ITGA6 targeting probe.
2. To validate the safety and effectiveness of the proposed ITGA6 targeting probes for clinical application.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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RDCy7 Intraoperative Fluorescence
The patients will receive an injection of fluorophore (RDCy7) before the surgery. Then intraoperative fluorescence imaging will be performed to guide lesion resection.
RD-Cy7 fluorophore
Fluorophore targeting ITGA6 that is overexpressed in HCC cells
Interventions
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RD-Cy7 fluorophore
Fluorophore targeting ITGA6 that is overexpressed in HCC cells
Eligibility Criteria
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Inclusion Criteria
2. Planned to receive hepatectomy.
3. Liver function Child-Pugh A.
4. ITGA6 was validated highly expressed preoperatively.
5. Aged 18 to 80, and the expected lifetime is longer than 6 months.
6. Approved to sign the informed consent.
Exclusion Criteria
2. Enrolled in other trials in the past 3 months.
3. Another malignant tumor was found.
4. Undesirable function of heart, lung, kidney, or any other organs.
5. Unable to tolerate a hepatectomy.
6. The researchers considered inappropriate to be included.
18 Years
80 Years
ALL
No
Sponsors
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Institute of Automation, Chinese Academy of Sciences
OTHER
Responsible Party
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Zhenhua Hu
Professor
Principal Investigators
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Zhenhua Hu, Ph. D
Role: PRINCIPAL_INVESTIGATOR
Institute of Automation, Chinese Academy of Sciences
Locations
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Guangdong
Guangzhou, Guangdong, China
Sichuan
Luzhou, Sichuan, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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ITGARD7
Identifier Type: -
Identifier Source: org_study_id
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