Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
10000 participants
OBSERVATIONAL
2016-11-15
2027-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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FAMILY_BASED
PROSPECTIVE
Study Groups
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Families with a history of Alzheimer's Disease
Families with two or more family members affected with Alzheimer's Disease
Blood Draw
Collection of blood samples for genetic testing
Late Onset Alzheimer's Disease (LOAD) Neuropsychological Battery Test
Memory Test
Un-related, non-demented controls
Un-related, non-demented healthy controls over age 55
Blood Draw
Collection of blood samples for genetic testing
Late Onset Alzheimer's Disease (LOAD) Neuropsychological Battery Test
Memory Test
Individuals with Dementia (Alzheimer's Disease)
Individuals with dementia over the age of 65
Blood Draw
Collection of blood samples for genetic testing
Late Onset Alzheimer's Disease (LOAD) Neuropsychological Battery Test
Memory Test
Interventions
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Blood Draw
Collection of blood samples for genetic testing
Late Onset Alzheimer's Disease (LOAD) Neuropsychological Battery Test
Memory Test
Eligibility Criteria
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Inclusion Criteria
* a living sibling with probable or possible AD;
* a third living relative affected with AD (onset age 50 or older) or unaffected (60 or older);
* participants in the proband's generation with an identified companion serving as an informant;
* participants who have capacity to consent or participants lacking capacity to consent with a surrogate/proxy in place to provide consent.
Exclusion Criteria
* uncertainty of the clinical diagnosis of Alzheimer's disease or other related disorder;
* discovery of additional diagnosis that could account for the clinical manifestations;
* unwillingness to participate;
* failure to identify a living sibling with AD or other related disorder (except in the cases of sporadic FTD and sporadic LBD);
* participants lacking the capacity to consent who do not have a surrogate or proxy or next of kin to provide consent.
55 Years
ALL
Yes
Sponsors
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National Institute on Aging (NIA)
NIH
Columbia University
OTHER
Responsible Party
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Principal Investigators
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Richard P. Mayeux, MD, MSc
Role: PRINCIPAL_INVESTIGATOR
Columbia University
Locations
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University of Washington
Washington D.C., District of Columbia, United States
University of Miami
Miami, Florida, United States
Rush University
Aurora, Illinois, United States
Indiana University
Bloomington, Indiana, United States
NCRAD at Indiana University
Indianapolis, Indiana, United States
Mayo Clinic
Rochester, Minnesota, United States
Joanne Norton
St Louis, Missouri, United States
Columbia University Irving Medical Center
New York, New York, United States
North Carolina State University
Raleigh, North Carolina, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
University of Texas Southwestern
Dallas, Texas, United States
University of Washington
Seattle, Washington, United States
Countries
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Central Contacts
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Facility Contacts
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Sarah Payne
Role: primary
Larry Deon
Role: primary
Corey Woods
Role: primary
Kelly Farber
Role: primary
Kelly Farber
Role: primary
Christine Hanzel
Role: primary
Joanne Norton
Role: primary
Takiyah Starks
Role: primary
Elise Weamer
Role: primary
Amy Browning
Role: primary
Other Identifiers
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AAAP0479
Identifier Type: -
Identifier Source: org_study_id
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