One-visit Root Canal Treatment Using Chlorhexidine as a Final Irrigant

NCT ID: NCT05006209

Last Updated: 2021-08-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-06-01

Study Completion Date

2021-04-01

Brief Summary

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A hundred asymptomatic molar teeth with periapical lesions were treated in single versus multiple visit root canal treatment. Half of the teeth were randomly assigned to the one-visit (OV) group and received an additional final rinse with 2% CHX before obturation. The other teeth were treated in two visits (TV) with calcium hydroxide dressing. All patients were recalled and investigated clinically and radiographically for 48 months

Detailed Description

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The aim of the study was to evaluate the radiographic evidence of periapical healing in teeth with apical periodontitis treated in a single visit with an additional final irrigation using 2% chlorhexidine and to compare the results with conventional multiple-visit root canal treatment (RCT) with an intracanal calcium hydroxide dressing as a control group. 100 asymptomatic molar teeth with periapical lesions were treated using engine-driven nickel-titanium (NiTi) instrumentation with 2.5% sodium hypochlorite (NaOCl) and 5% ethylenediaminetetraacetic acid (EDTA) as irrigants. Half of the teeth were randomly assigned to the one-visit (OV) group and received an additional final rinse with 2% chlorhexidine (CHX) before obturation. The other teeth were treated in two visits (TV), after completion of root canal instrumentation calcium hydroxide paste was placed into the root canal and root canal obturation was performed in second visit. All patients were recalled and investigated clinically and radiographically for 48 months. Changes in apical bone density indicating radiographic healing were evaluated.

Conditions

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Root Canal Infection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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One visit root canal treatment with CHX

The teeth were treated in one-visit (OV) root canal treatment. Final root canal irrigation was performed with 5% EDTA, followed by 2.5% NaOCl and received an additional final rinse with 2% CHX before obturation.

Group Type ACTIVE_COMPARATOR

One visit root canal treatment

Intervention Type OTHER

Two visit root canal treatment with CH

The teeth were treated in two visit (TV) root canal treatment. After completion of root canal instrumentation, calcium hydroxide (CH) paste was placed into the root canal. In second visit, all root canals were irrigated with 5% EDTA followed by 2.5% NaOCl before obturation.

Group Type ACTIVE_COMPARATOR

Two visit root canal treatment

Intervention Type OTHER

Interventions

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One visit root canal treatment

Intervention Type OTHER

Two visit root canal treatment

Intervention Type OTHER

Other Intervention Names

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CHX Calcium hydroxide

Eligibility Criteria

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Inclusion Criteria

* with a non-contributory medical history,
* mature molar teeth with periapical lesions,
* diagnosed as asymptomatic apical periodontitis

Exclusion Criteria

* clinical symptoms, drainage,
* more than 5 mm loss of periodontal attachment,
* previous endodontic treatment,
* non-restorable tooth
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ege University

OTHER

Sponsor Role lead

Responsible Party

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Seniha Miçooğulları Kurt

Principle investigator, Asst. Assoc. Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Seniha Miçooğulları Kurt

Role: PRINCIPAL_INVESTIGATOR

Ege University Faculty of Dentistry

References

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Micoogullari Kurt S, Caliskan MK. Efficacy of chlorhexidine as a final irrigant in one-visit root canal treatment: a prospective comparative study. Int Endod J. 2018 Oct;51(10):1069-1076. doi: 10.1111/iej.12931. Epub 2018 Apr 23.

Reference Type BACKGROUND
PMID: 29603299 (View on PubMed)

Paredes-Vieyra J, Enriquez FJ. Success rate of single- versus two-visit root canal treatment of teeth with apical periodontitis: a randomized controlled trial. J Endod. 2012 Sep;38(9):1164-9. doi: 10.1016/j.joen.2012.05.021. Epub 2012 Jul 26.

Reference Type BACKGROUND
PMID: 22892729 (View on PubMed)

Siqueira JF Jr, Rocas IN. Optimising single-visit disinfection with supplementary approaches: a quest for predictability. Aust Endod J. 2011 Dec;37(3):92-8. doi: 10.1111/j.1747-4477.2011.00334.x.

Reference Type BACKGROUND
PMID: 22117714 (View on PubMed)

Other Identifiers

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one-visit root canal treatment

Identifier Type: -

Identifier Source: org_study_id

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