Diagnostic Reliability of OCT Biomarkers for iERM

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

136 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-11

Study Completion Date

2021-08-21

Brief Summary

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Several optical coherence tomography (OCT) biomarkers with potential to influence postsurgical outcomes after vitrectomy with membrane peeling for idiopathic epiretinal membranes (iERM) have been described in single predictor analyses in the past. Aim of the study is to assess the reliability of diagnosis of OCT biomarkers and to calculate their impact on postsurgical visual acuity in a multiple regression analysis.

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Detailed Description

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Several optical coherence tomography (OCT) biomarkers with potential to influence postsurgical outcomes after vitrectomy with membrane peeling for idiopathic epiretinal membranes (iERM) have been described in single predictor analyses in the past. A recent multifactorial analysis outlined macular thickness and DRIL to be significant predictors for postsurgical visual acuity (Karasavviodou et al.). Nevertheless, reliability of diagnosing OCT biomarkes among patients with iERM was not yet assessed, to our knowledge. Aim of the study is to assess the reliability of diagnosis of OCT biomarkers and to calculate their impact on postsurgical visual acuity in a multiple regression analysis.

Conditions

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Idiopathic Epiretinal Membranes

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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Study Group

Biomarkers from presurgical OCTs are diagnosed

Biomarker analysis

Intervention Type OTHER

Biomarkers from presurgical OCTs are assessed

Interventions

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Biomarker analysis

Biomarkers from presurgical OCTs are assessed

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* a) presence of an iERM,
* b) indication for membrane peeling, defined as significant loss of visual acuity and/or metamorphopsia due to the ERM,
* c) pseudophakia at the final visit at 3 months after surgery, and
* d) written informed consent for study participation.