Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children
NCT ID: NCT04993859
Last Updated: 2025-10-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
152 participants
OBSERVATIONAL
2021-06-02
2026-07-09
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Male Cancer Survivors with DVSS Score ≥ 9
Childhood cancer survivors treated with DOX and/or VCR with evidence of BD on DVSS
Non-invasive Urodynamic Test (niUDS)
A noninvasive urodynamics is a simple test used to evaluate urinary flow.
Urinary proteomic screen
Urine proteomics is a powerful platform to identify urinary excreted proteins and peptides in different stages of disease or therapy and to determine their quantity, functions, and interaction.
Dysfunctional Voiding Symptom Score Survey (DVSS)
The Dysfunctional Voiding Symptom Score provides accurate and objective grading of voiding behaviors of children.
Female Cancer Survivors with DVSS Score ≥ 6
Childhood cancer survivors treated with DOX and/or VCR with evidence of BD on DVSS
Non-invasive Urodynamic Test (niUDS)
A noninvasive urodynamics is a simple test used to evaluate urinary flow.
Urinary proteomic screen
Urine proteomics is a powerful platform to identify urinary excreted proteins and peptides in different stages of disease or therapy and to determine their quantity, functions, and interaction.
Dysfunctional Voiding Symptom Score Survey (DVSS)
The Dysfunctional Voiding Symptom Score provides accurate and objective grading of voiding behaviors of children.
Male Cancer Survivors with DVSS Score < 9
Childhood cancer survivors treated with DOX and/or VCR without evidence of BD on DVSS
Non-invasive Urodynamic Test (niUDS)
A noninvasive urodynamics is a simple test used to evaluate urinary flow.
Urinary proteomic screen
Urine proteomics is a powerful platform to identify urinary excreted proteins and peptides in different stages of disease or therapy and to determine their quantity, functions, and interaction.
Dysfunctional Voiding Symptom Score Survey (DVSS)
The Dysfunctional Voiding Symptom Score provides accurate and objective grading of voiding behaviors of children.
Female Cancer Survivors with DVSS Score < 6
Childhood cancer survivors treated with DOX and/or VCR without evidence of BD on DVSS
Non-invasive Urodynamic Test (niUDS)
A noninvasive urodynamics is a simple test used to evaluate urinary flow.
Urinary proteomic screen
Urine proteomics is a powerful platform to identify urinary excreted proteins and peptides in different stages of disease or therapy and to determine their quantity, functions, and interaction.
Dysfunctional Voiding Symptom Score Survey (DVSS)
The Dysfunctional Voiding Symptom Score provides accurate and objective grading of voiding behaviors of children.
Interventions
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Non-invasive Urodynamic Test (niUDS)
A noninvasive urodynamics is a simple test used to evaluate urinary flow.
Urinary proteomic screen
Urine proteomics is a powerful platform to identify urinary excreted proteins and peptides in different stages of disease or therapy and to determine their quantity, functions, and interaction.
Dysfunctional Voiding Symptom Score Survey (DVSS)
The Dysfunctional Voiding Symptom Score provides accurate and objective grading of voiding behaviors of children.
Eligibility Criteria
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Inclusion Criteria
* A history of cancer
* Treatment with a chemotherapy regimen including VCR and/or DOX
* Completion of chemotherapy at least one year prior to study enrollment and survey completion.
Exclusion Criteria
* Primary pelvic tumor
* Pelvic irradiation
* Pre-existing bladder/bowel dysfunction
* Spinal defects
* Neurologic disorder
* Neuro-oncologic tumor or brain metastasis
* Cyclophosphamide or ifosfamide therapy
5 Years
13 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Children's Hospital Colorado
OTHER
University of Colorado, Denver
OTHER
Responsible Party
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Principal Investigators
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Nicholas Cost, MD
Role: PRINCIPAL_INVESTIGATOR
Children's Hospital Colorado
Locations
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Children's Hospital Colorado
Aurora, Colorado, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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