A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer

NCT ID: NCT04931654

Last Updated: 2025-10-09

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 136 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-09-28
• Study Completion Date: 2026-08-12

Brief Summary

This is a Phase I/IIa study designed to evaluate if experimental anti-PD-1 and anti-TIM-3 bispecific antibody, AZD7789 is safe, tolerable and efficacious in participants with advanced solid tumors.

Detailed Description

This first time in patients, open-label, multi-centre study will have AZD7789 administered intravenously (IV) to participants with advanced solid tumors. This study will have 2 parts: Part A which will have dose escalation cohorts and Part B which will have the dose expansion cohorts.

Conditions

Carcinoma, Non-Small-Cell Lung; Gastric Cancer; Gastroesophageal Junction Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Dose Escalation Part A: NSCLC Immuno-oncology (IO) acquired or primary resistance

AZD7789 monotherapy

Group Type: EXPERIMENTAL

AZD7789

Intervention Type: DRUG

anti-PD-1 and anti-TIM-3 bispecific antibody

Dose Expansion Part B1: NSCLC IO acquired resistance - RP2D level 1

AZD7789 Monotherapy

Group Type: EXPERIMENTAL

AZD7789

Intervention Type: DRUG

anti-PD-1 and anti-TIM-3 bispecific antibody

Dose Expansion Part B2: NSCLC IO naive, PD-L1 50% or greater - RP2D level 1

AZD7789 Monotherapy

Group Type: EXPERIMENTAL

AZD7789

Intervention Type: DRUG

anti-PD-1 and anti-TIM-3 bispecific antibody

Dose Expansion Part B3: NSCLC IO acquired resistance - RP2D level 2

AZD7789 Monotherapy

Group Type: EXPERIMENTAL

AZD7789

Intervention Type: DRUG

anti-PD-1 and anti-TIM-3 bispecific antibody

Dose Expansion Part B4: advanced or metastatic gastric and GEJC IO acquired resistance- RP2D level 1

AZD7789 monotherapy

Group Type: EXPERIMENTAL

AZD7789

Intervention Type: DRUG

anti-PD-1 and anti-TIM-3 bispecific antibody

Dose Expansion Part B5: NSCLC IO naive, PD-L1 1-49% - RP2D Level 1

AZD7789 monotherapy

Group Type: EXPERIMENTAL

AZD7789

Intervention Type: DRUG

anti-PD-1 and anti-TIM-3 bispecific antibody

Interventions

AZD7789

anti-PD-1 and anti-TIM-3 bispecific antibody

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Must be ≥ 18 years of age
• Part A Dose-escalation cohorts and Part B Dose-expansion cohorts B1, B2, B3 and B5: Histologically or cytologically documented Stage IIIB to IV non-small cell lung carcinoma (NSCLC) not amenable to curative surgery or radiation.
• Part B Dose-expansion cohort B4: Histologically or cytologically documented advanced or metastatic gastric and gastro-esophageal junction adenocarcinoma (GEJC) not amenable to curative surgery or radiation.
• Must have at least one measurable lesion according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
• Provision of archival or fresh tumor tissue sample and/or consent to undergo mandatory on-treatment biopsy for participants enrolled in Part A Dose-escalation
• Provision of archival tumor tissue sample or fresh tissue sample for Part B Dose-expansion cohorts B1, B2, B3 and B5. Provision of fresh tumor tissue sample and consent to undergo mandatory on-treatment biopsy for cohort B4.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
• Non-pregnant women and willingness of female participants to avoid pregnancy or male participants willing to avoid fathering children through highly effective methods of contraception
• Adequate organ and bone marrow function measured within 28 days prior to first dose

• May have squamous or non-squamous NSCLC
• Must have received at least one prior line of systemic therapy, of which at least one prior line of therapy contained approved anti-PD-1/PD-L1
• Must have had immune-oncology (IO) acquired or primary resistance
• PD-L1 expression < 1% or ≥ 1% documented

• May have squamous or non-squamous NSCLC
• Must have received at least one prior line of systemic therapy, of which only one prior line of therapy contained approved anti-PD-1/PD-L1
• Must have had IO acquired resistance
• PD- L1 expression ≥ 1% documented

• May have squamous or non-squamous NSCLC
• Must not have received prior IO therapy in the first-line setting, but may have received one prior treatment regime of platinum-based chemotherapy
• Cohort B2: PD-L1 expression ≥ 50% documented
• Cohort B5: PD-L1 expression 1-49% documented

• Must have received at least one but no more than two prior lines of systemic therapy, of which only one prior line of therapy contained an approved anti-PD-1/PD-L1
• Must have had IO acquired resistance
• There are no PD-L1 status requirements for this cohort

Exclusion Criteria

• Patients with sensitizing epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) fusions. Documented test result is mandatory for participants with non-squamous NSCLC histology. For participants with squamous NSCLC histology, testing is mandatory only if the participant is a never-smoker or in the presence of a mixed histology.
• Documented test result for any other known genomic alteration for which a targeted first line therapy is approved per local standard of care (SoC)
• Part B Dose-expansion Cohort B4: documented HER2 amplification (unless a SoC including an anti-HER2 therapy has been received); testing is not mandatory if not required per local guidelines.
• Unresolved toxicities of ≥ Grade 2 from prior therapy
• Any prior ≥ Grade 3 immune-mediated adverse event (imAE) while receiving immunotherapy or any unresolved imAE ≥ Grade 2
• Must not have experienced a toxicity that led to permanent discontinuation of prior immunotherapy
• Symptomatic central nervous system (CNS) metastasis or leptomeningeal disease
• History of symptomatic and objectively confirmed arterial (including myocardial infarction) or venous thromboembolic event within 6 months prior to the first dose of study intervention, unless participant is on treatment with adequate antithrombotic medication and is considered to be stable by the Investigator.
• History of organ transplant or allogenic haematopoietic stem cell transplant
• Infectious disease exclusions: Active infection including TB, HIV, hepatitis A, chronic or active hepatitis B, chronic or active hepatitis C, active COVID-19 infection
• History of clinically significant arrythmia as judged by the Investigator
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, cardiomyopathy of any etiology, symptomatic congestive heart failure, uncontrolled hypertension, uncontrolled diabetes mellitus, unstable angina pectoris, history of myocardial infarction within the past 6 months, serious chronic gastrointestinal conditions associated with diarrhea, active non infectious skin disease. Part B Dose-expansion Cohort B4, medication-resistant ascites requiring drainage in the last 28 days prior the start of AZD7789 and/or the occurrence of active gastro-intestinal bleeding, as judged by the Investigator.
• Active or prior documented autoimmune or inflammatory disorders, including inflammatory bowel disease (eg, colitis or Crohn's disease), diverticulitis (with the exception of diverticulosis), systemic lupus erythematosus, Sarcoidosis syndrome, or Wegener syndrome (granulomatosis with polyangiitis), Graves' disease, rheumatoid arthritis, hypophysitis, uveitis, etc.. Some exceptions have been specified in the protocol
• Past medical history of interstitial lung disease (ILD), drug-induced ILD, radiation pneumonitis requiring steroid treatment, or any evidence of clinically active ILD
• Major surgical procedure within 28 days prior to the first dose of study intervention or still recovering from prior surgery
• Other invasive malignancy within 2 years prior to screening
• Congenital long QT syndrome or history of QT prolongation associated with other medications that cannot be changed or discontinued based on a cardiologist assessment
• Any previous treatment with anti-TIM-3 therapy in any setting is not permitted. For Part A, Cohorts B1 and B3:treatment with investigational therapy prior to initiation of study treatment except where the most recent line of therapy was investigational agents added to approved anti-PD-1/PD-L1 as part of standard care. Investigational agents may be given as prior lines of therapy (other than the most recent line) and as monotherapy. Where investigational agents are the most recent line of therapy, they must be given in combination with approved anti-PD-1/PD-L1. For Part B Dose-expansion Cohort B4: investigational agents, other than investigational immune checkpoint inhibitors or other IO agents, may be given as any prior lines of therapy.
• Current or prior use of immunosuppressive medication within 14 days prior to the first dose of study intervention
• Any concurrent chemotherapy, radiotherapy, investigational, biologic, or hormonal therapy for cancer treatment. Concurrent use of hormonal therapy for noncancer-related conditions is acceptable.
• Receipt of live attenuated vaccine within 30 days prior to the first dose of study intervention Note: Participants should not receive live vaccine while receiving study intervention and up to 30 days after the last dose of study intervention
• Radiotherapy treatment to the lung within ≤ 4 weeks of the first dose of AZD7789. Palliative bone radiotherapy is allowed if ≥ 2 weeks prior to the first dose of AZD7789.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 130 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

AstraZeneca

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Research Site

Atlanta, Georgia, United States

Research Site

Fort Wayne, Indiana, United States

Research Site

New York, New York, United States

Research Site

Nashville, Tennessee, United States

Research Site

Toronto, Ontario, Canada

Research Site

Beijing, , China

Research Site

Guangzhou, , China

Research Site

Bordeaux, , France

Research Site

Rennes, , France

Research Site

Villejuif, , France

Research Site

Tbilisi, , Georgia

Research Site

Chūōku, , Japan

Research Site

Kashiwa, , Japan

Research Site

Chisinau, , Moldova

Research Site

Amsterdam, , Netherlands

Research Site

Barcelona, , Spain

Research Site

Madrid, , Spain

Research Site

Ankara, , Turkey (Türkiye)

Research Site

Ankara, , Turkey (Türkiye)

Research Site

Ankara, , Turkey (Türkiye)

Research Site

Karşıyaka, , Turkey (Türkiye)

Countries

United States; Canada; China; France; Georgia; Japan; Moldova; Netherlands; Spain; Turkey (Türkiye)

Other Identifiers

152970

Identifier Type: REGISTRY

Identifier Source: secondary_id

2022-502774-17

Identifier Type: REGISTRY

Identifier Source: secondary_id

2021-000036-57

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

D9570C00001

Identifier Type: -

Identifier Source: org_study_id