The Safety and PK Characteristics of the Co-administration of JLP-2002 and Comparator in Healthy Volunteers

NCT ID: NCT04914221

Last Updated: 2021-06-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

42 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-03-13

Study Completion Date

2021-05-26

Brief Summary

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A randomized, open-label, single-dose, replicate crossover study to compare the pharmacokinetics and safety in healthy adult volunteers following oral administration of JLP-2002

Detailed Description

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A randomized, open-label, single-dose, replicate crossover study

Conditions

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Overactive Bladder(OAB)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group I

Period I- comparator / Period II- comparator / Period III-JLP-2002

Group Type EXPERIMENTAL

JLP-2002

Intervention Type DRUG

administration of JLP-2002

Comparator

Intervention Type DRUG

administration of comparator

Group II

Period I- comparator / Period II- -JLP-2002 / Period III- comparator

Group Type EXPERIMENTAL

JLP-2002

Intervention Type DRUG

administration of JLP-2002

Comparator

Intervention Type DRUG

administration of comparator

Group III

Period I- JLP-2002/ Period II- comparator / Period III- comparator

Group Type EXPERIMENTAL

JLP-2002

Intervention Type DRUG

administration of JLP-2002

Comparator

Intervention Type DRUG

administration of comparator

Interventions

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JLP-2002

administration of JLP-2002

Intervention Type DRUG

Comparator

administration of comparator

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Those who are 19 years of age or older and 55 years of age
* BMI 18.5 \~ 27.5 kg/m2
* Those who voluntarily agrees in writing after hearing a sufficient explanation of the purpose and procedure of the clinical trial

Exclusion Criteria

* Those with clinically significant diseases or a history of liver, kidney, cardiovascular system, endocrine system, musculoskeletal system, respiratory system, neuropsychiatric system, blood/oncology system, etc.
* Those with a history of gastrointestinal diseases or surgery that may affect the absorption of drugs
* Those who donated whole blood within 60 days from the date of eligibility assessment, or who donated component blood within 30 days
* Those who do not have a medically recognized contraceptive intention or plan to provide sperm from the screening date to 4 weeks from the last administration of the investigational drug
* Those whose blood AST, ALT, or GGT levels in the screening test exceeded 3 times the upper limit of the reference range
* Those who showed clinically significant results in the hepatitis B test, hepatitis C test, HIV test, and syphilis test
* In the case of women, those who do not show a negative response on the pregnancy test
* Those who judged that the investigator is not suitable for participation in clinical trials, such as showing clinically significant results in other screening tests
Minimum Eligible Age

19 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Jeil Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Samsung Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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JLP-2002-101-PK

Identifier Type: -

Identifier Source: org_study_id

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