The Relationship Between HLA Tissue Compatibility and Biliary Complications in Patients With Liver Transplantation

NCT ID: NCT04885582

Last Updated: 2021-05-13

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-05-10
• Study Completion Date: 2020-05-20

Brief Summary

Liver transplantation has become the accepted treatment option for advanced liver failure in recent years. In addition to the increase in the number of centers performing transplant and the decrease in complication rates depending on the experience gained, the most common biliary complications did not improve at the desired level. For this reason, studies in this field are frequent today.

The structural complexities of HLA antigens have been the subject of investigation in recent years. With the development of DNA and RNA amplification methods; It is increasingly difficult for physicians to keep up with the increasing burden of knowledge regarding the genetic aspects of these antigens. Concrete benefits of this gene complex, which has been investigated in various fields and preserves its mystery, have not been determined in liver transplant patients. However, there are publications showing its connection with the bile epithelium in liver transplantation and its relationship with the disappearing bile duct syndrome. In this study, our aim is to explain whether the bile duct complications, which appear like a continuous wall and can lead to frightening pictures, are related to HLA tissue compatibility.

Conditions

Liver Transplant; Complications; HLA Antigens

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Patients with biliary complications

patients with postoperative biliary fistula, biliary stenosis

HLA antigen results

Intervention Type: OTHER

HLA-A, HLA-B, HLA-DR tissue matching results in both groups will be compared.

Patients without biliary complications

patients without postoperative biliary fistula and biliary stenosis

HLA antigen results

Intervention Type: OTHER

HLA-A, HLA-B, HLA-DR tissue matching results in both groups will be compared.

Interventions

HLA antigen results

HLA-A, HLA-B, HLA-DR tissue matching results in both groups will be compared.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• patients with liver transplantation and tested for HLA antigen (recipient - donor)

Exclusion Criteria

• patients who died early Patients whose HLA antigen is not checked

• Minimum Eligible Age: 1 Year
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Inonu University

OTHER

Sponsor Role: lead

Responsible Party

Ersin Gündoğan

Assoc Prof

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Health science University - Kayseri State Hospital

Kocasinan, Kayseri, Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

2017/133

Identifier Type: -

Identifier Source: org_study_id