Prevalence of Traumatic Events and PTSD in Immigrant and Non-immigrant Patients With Psychotic Disorder
NCT ID: NCT04867447
Last Updated: 2023-07-06
Study Results
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Basic Information
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COMPLETED
199 participants
OBSERVATIONAL
2019-09-01
2023-03-01
Brief Summary
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The aim of this research is to study the association between psychosis and traumatic events exposure/PTSD in immigrant population. Our hypothesis is that the higher incidence of psychosis described in immigrant population is associated to higher trauma exposure.
A case-control observational study is performed. Patients who presented at least one psychotic episode are recruited from acute and chronic units at "Parc Salut Mar" (Barcelona). Estimated total sample is 196 individuals. Trauma exposure is assessed by validated trauma scales. Known factors associated with psychosis are controled during the statistic analysis.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Case-Immigrants psychotic patients
Individuals who have presented at least one non-affective psychotic episode with an immigrant status, defined as "a person who migrates to another country, usually for permanent residence"
Psychological trauma evaluation
Psychological trauma exposure is assessed by validated scales:
* Childhood Trauma Questionnaire (CTQ)
* Clinician-Administered PTSD Scale for DSM-5 (CAPS-5)
* Cumulative Trauma Scale.
* The Holmes and Rahe Stress Scale.
Other clinical scales used:
* Positive and Negative Syndrome Scale (PANSS).
* Dissociative Experiences Scale (DES)
* Mini-Mental State Examination (MMSE).
Control-Non immigrants psychotic patients
Individuals who have presented at least one non-affective psychotic episode who do not have an immigrant status.
Psychological trauma evaluation
Psychological trauma exposure is assessed by validated scales:
* Childhood Trauma Questionnaire (CTQ)
* Clinician-Administered PTSD Scale for DSM-5 (CAPS-5)
* Cumulative Trauma Scale.
* The Holmes and Rahe Stress Scale.
Other clinical scales used:
* Positive and Negative Syndrome Scale (PANSS).
* Dissociative Experiences Scale (DES)
* Mini-Mental State Examination (MMSE).
Interventions
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Psychological trauma evaluation
Psychological trauma exposure is assessed by validated scales:
* Childhood Trauma Questionnaire (CTQ)
* Clinician-Administered PTSD Scale for DSM-5 (CAPS-5)
* Cumulative Trauma Scale.
* The Holmes and Rahe Stress Scale.
Other clinical scales used:
* Positive and Negative Syndrome Scale (PANSS).
* Dissociative Experiences Scale (DES)
* Mini-Mental State Examination (MMSE).
Eligibility Criteria
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Inclusion Criteria
* Patients of non-local origins who have undergone a migration process along the life line (as case individuals) and autochthonous patients (as control individuals).
* Age between 18 and 65 years.
Exclusion Criteria
* Important cognitive limitations to understand informed consent nor applied questionnaires.
* Language barrier that limits understanding informed consent nor applied questionnaires.
18 Years
65 Years
ALL
No
Sponsors
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Universitat Autonoma de Barcelona
OTHER
Parc de Salut Mar
OTHER
Responsible Party
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Principal Investigators
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Amira Trabsa Biskri, MD
Role: PRINCIPAL_INVESTIGATOR
Institut Hospital del Mar d'Investigacions Mèdiques (IMIM)
Locations
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Unidad de Investigación del Centro Fórum y Instituto Hospital del Mar de Investigaciones Médicas.
Barcelona, , Spain
Countries
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References
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Betancourt TS, Newnham EA, Birman D, Lee R, Ellis BH, Layne CM. Comparing Trauma Exposure, Mental Health Needs, and Service Utilization Across Clinical Samples of Refugee, Immigrant, and U.S.-Origin Children. J Trauma Stress. 2017 Jun;30(3):209-218. doi: 10.1002/jts.22186. Epub 2017 Jun 6.
Cantor-Graae E, Selten JP. Schizophrenia and migration: a meta-analysis and review. Am J Psychiatry. 2005 Jan;162(1):12-24. doi: 10.1176/appi.ajp.162.1.12.
Anderson KK, Edwards J. Age at migration and the risk of psychotic disorders: a systematic review and meta-analysis. Acta Psychiatr Scand. 2020 May;141(5):410-420. doi: 10.1111/acps.13147. Epub 2020 Jan 20.
Hollander AC, Dal H, Lewis G, Magnusson C, Kirkbride JB, Dalman C. Refugee migration and risk of schizophrenia and other non-affective psychoses: cohort study of 1.3 million people in Sweden. BMJ. 2016 Mar 15;352:i1030. doi: 10.1136/bmj.i1030.
Selten JP, Hoek HW. Does misdiagnosis explain the schizophrenia epidemic among immigrants from developing countries to Western Europe? Soc Psychiatry Psychiatr Epidemiol. 2008 Dec;43(12):937-9. doi: 10.1007/s00127-008-0390-5. No abstract available.
Gibson LE, Alloy LB, Ellman LM. Trauma and the psychosis spectrum: A review of symptom specificity and explanatory mechanisms. Clin Psychol Rev. 2016 Nov;49:92-105. doi: 10.1016/j.cpr.2016.08.003. Epub 2016 Aug 31.
Howes OD, McCutcheon R. Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization. Transl Psychiatry. 2017 Feb 7;7(2):e1024. doi: 10.1038/tp.2016.278.
Trabsa A, Redolar-Ripoll D, Vargas L, Llimona A, Hogg B, Valiente-Gomez A, Perez V, Moreno-Alcazar A, Amann BL. A comparison of PTSD and traumatic event rates in a clinical sample of non-refugee immigrants and native-born individuals with a psychotic disorder: a case-control study. Eur J Psychotraumatol. 2023;14(2):2263151. doi: 10.1080/20008066.2023.2263151. Epub 2023 Oct 17.
Other Identifiers
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2019/8398/I
Identifier Type: -
Identifier Source: org_study_id
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