Evaluating the Neurobiological Basis of Traumatic Dissociation in Women With Histories of Abuse and Neglect

NCT ID: NCT02757339

Last Updated: 2025-10-27

Basic Information

• Recruitment Status: ENROLLING_BY_INVITATION
• Total Enrollment: 200 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-06-30
• Study Completion Date: 2026-06-30

Brief Summary

This study aims to evaluate the neurobiological basis of traumatic dissociation in a cross-diagnostic sample of women who have histories of childhood abuse and neglect.

Detailed Description

Dissociative symptoms commonly are associated with exposure to traumatic stress. Preliminary evidence from functional magnetic resonance imaging-based analysis (fMRI) of neural activation during dissociative symptom provocation in patients with PTSD or DID has implicated certain key structures involved in the generation of dissociative symptoms. Given the presumed region-to-region neural interplay implicit within this model, the investigators believe the use of intrinsic functional connectivity MRI (fcMRI) represents a valuable next line of investigation into the neurobiology of traumatic dissociation. The investigators also believe that a genetic approach holds promise as another converging line of inquiry into our understanding of traumatic dissociation.

To evaluate the neurobiological basis of traumatic dissociation, this study will recruit patients with PTSD or DID, and recruit matched controls to identify neurobiological correlates of traumatic dissociation.The study will compare the phenomenology of traumatic dissociation in patients with different PTSD subtypes and DID using standardized measures to look at the neurological and genetic correlates.

This study will also include a follow up visit that includes neuroimaging and genetic assessments.

Conditions

Posttraumatic Stress Disorders; Dissociative Identity Disorder

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Women with History of Childhood Abuse

The study will enroll up to 140 female patients with either DID or PTSD ages 18-89

No interventions assigned to this group

Healthy Control Group

We will recruit up to 60 control subjects matched for demographics (age, race, gender).

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Female
• Clinical diagnosis of PTSD or DID and history of childhood abuse, or healthy controls
• Age between 18 and 89
• Legal and mental competency of the patient

Exclusion Criteria

• Male
• Under 18 or over 89
• Legal or mental incompetence
• Delirium secondary to medical illness
• PTSD or DID due to general medical or neurological illness
• History of neurological conditions that may cause significant psychiatric symptomatology (e.g., dementia)
• Any contraindication to MR scans, including claustrophobia, pregnancy, metal implants, etc.
• Current alcohol or substance dependence or abuse (within the last month)
• A history of schizophrenia or other psychotic disorder
• History of head injury or loss of consciousness for longer than 5 min (including concussion)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 89 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Mclean Hospital

OTHER

Sponsor Role: lead

Responsible Party

Milissa Kaufman

Director of The Dissociative Disorders and Trauma Research Program

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Milissa L Kaufman, M.D./Ph.D

Role: PRINCIPAL_INVESTIGATOR

Mclean Hospital

Locations

McLean Hospital

Belmont, Massachusetts, United States

Countries

United States

Other Identifiers

2014P001429

Identifier Type: -

Identifier Source: org_study_id