Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
78 participants
INTERVENTIONAL
2014-01-31
2018-12-31
Brief Summary
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Detailed Description
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The proposed studies aim to further investigate these findings and to understand the underlying neuronal correlates. Thus, the mechanisms of enhanced memory retrieval after hydrocortisone in patients with BPD and PTSD will be investigated by fMRI.
In a placebo-controlled study, the effects of 10mg hydrocortisone on brain activity, in particular the hippocampus, will be investigated in patients with PTSD and BPD and will be compared with those in healthy control participants. During the fMRI session, a declarative memory task (retrieval of a previous learned word list) and an autobiographical memory test will be performed. Effects of hydrocortisone on resting state brain activity and the neuronal correlates of memory retrieval will be analysed.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Hydrocortisone
10 mg hydrocortisone orally
Hydrocortisone
effects of hydrocortisone on memory while fMRI
Placebo
placebo orally
Placebo
Interventions
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Hydrocortisone
effects of hydrocortisone on memory while fMRI
Placebo
Eligibility Criteria
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Inclusion Criteria
* Clinical diagnosis of PTSD
* females without psychiatric disorders as control group
* right handed
18 Years
40 Years
FEMALE
Yes
Sponsors
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Charite University, Berlin, Germany
OTHER
Responsible Party
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Katja Wingenfeld
Prof. Dr.
Locations
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Charite University
Berlin, , Germany
Countries
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Other Identifiers
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WI-3396-2
Identifier Type: -
Identifier Source: org_study_id
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