Validation and Implementation of 3T MRI Research Protocols
NCT ID: NCT04866940
Last Updated: 2025-01-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
230 participants
INTERVENTIONAL
2021-05-12
2027-05-12
Brief Summary
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MRI is an evolving technique, which is used in many research projects. Our technical platform must follow these developments and remain at the cutting edge. One of the essential services of our technical platform is to help set up research protocols and validate acquisition sequences. This development activity is therefore located upstream of research projects involving clinical or fundamental applications. The fact that we can provide our users with a regulatory framework to carry out these development tests for their Research Involving Human Subjects project is a necessity for our research support activity.
This study aims to provide a generic framework to test the feasibility of MRI sequences requested within the framework of protocols, but also to optimize MRI acquisition sequences already in place, to improve image quality and reduce artifacts that can degrade the quality of the images obtained.
In France, there are just over 35 centers with MRI dedicated to research and therefore with a validation protocol allowing them to validate their sequences.
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Detailed Description
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At the end of the examination, the images obtained will be evaluated jointly by an expert neuroradiologist and a research engineer specialized in image analysis according to the criteria mentioned above. This analysis will make it possible to determine the parameters to be modified to improve image quality and to define the acquisition parameters for the next test.
As soon as a sequence is considered optimal, it will be tested on a small number of healthy controls (≈ 5) to ensure interindividual reproducibility of image quality parameters, and then if necessary in the presence of pathology in a few patients (≈ 5).
Conditions
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Study Design
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NA
SINGLE_GROUP
SCREENING
NONE
Study Groups
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Sequence validation
This research aims to provide a generic framework to test the feasibility of MRI sequences requested as part of protocols, but also to optimize MRI acquisition sequences already in place, to improve image quality and reduce artifacts that can degrade the quality of images obtained.
Sequences test
the realization of preliminary acquisitions to validate the feasibility of clinical or cognitive research protocols
Interventions
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Sequences test
the realization of preliminary acquisitions to validate the feasibility of clinical or cognitive research protocols
Eligibility Criteria
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Inclusion Criteria
* Ability to cooperate and remain motionless for up to 1 hour (and lying down for 1.5 hours)
* Ability to understand the instructions given
* Subject who has given written and informed consent prior to any examination required by the research)
* Subject affiliated to a social security system or benefiting from an equivalent system
Exclusion Criteria
* Psychiatric disorders, disorders of cognitive functions, not allowing the realization of the MRI
* Protected adults (subject to a measure of legal protection) or unable to express their consent
* Subject with Contraindications to MRI
18 Years
ALL
Yes
Sponsors
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Institut National de la Santé Et de la Recherche Médicale, France
OTHER_GOV
Responsible Party
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Principal Investigators
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Pierre PAYOUX, Pr
Role: PRINCIPAL_INVESTIGATOR
Inserm: UMR 1214 ToNIC
Locations
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UMR 1214 ToNIC INSERM
Toulouse, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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C20-28
Identifier Type: -
Identifier Source: org_study_id
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