Effect of Bilateral Transversus Thoracis Muscle Plane Block in Patients Undergoing Coronary Artery Bypass Graft Surgery.
NCT ID: NCT04849117
Last Updated: 2021-04-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
100 participants
OBSERVATIONAL
2018-01-01
2019-12-20
Brief Summary
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The aim of the study is to evualuate efficacy of bilateral transversus thoracis muscle plane (TTMP) block combined with systemic analgesia, compared to systemic analgesia only, in patients undergoing elective on-pump CABG surgery.
Our main hypothesis is that a bilateral TTMP block performed after CABG surgery could reduce morphine consumption during the first 48 hours.
The investigators conducted an age, gender and type of surgery-matched retrospective cohort study in the Montpellier University Hospital (France).
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Systemic analgesia
Patients received only systemic analgesia : Acetaminophen, Ketoprofen, and Nefopam were administered systematically. Morphine was administered if necessary, according to our institutional pain management protocol.
No interventions assigned to this group
Bilateral TTMP block + systemic analgesia
Patients received the same protocol of systemic analgesia associated with a bilateral TTMP block performed during the first four hours after ICU admission, before tracheal tube removal.
Ultrasound guided Bilateral Transversus Thoracis Muscle Plane block
In the "TTMP block" group, an ultrasounded guided TTMP block was performed by an anesthesiologist, in ICU, before tracheal tube removal. Between the 4th et 5th rib, on each side, 40 ml of Ropivacaine 2 mg/ml, in association with Clonidine, was injected "single-shot" in the tranversus thoracis muscle plane. The targets of local anesthetic were the anterior branches of intercostal nerves from T2 to T6. Dexamethasone 8 mg was injected intravenously.
Interventions
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Ultrasound guided Bilateral Transversus Thoracis Muscle Plane block
In the "TTMP block" group, an ultrasounded guided TTMP block was performed by an anesthesiologist, in ICU, before tracheal tube removal. Between the 4th et 5th rib, on each side, 40 ml of Ropivacaine 2 mg/ml, in association with Clonidine, was injected "single-shot" in the tranversus thoracis muscle plane. The targets of local anesthetic were the anterior branches of intercostal nerves from T2 to T6. Dexamethasone 8 mg was injected intravenously.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* To be scheduled for CABG surgery in the center of the study during the study period.
Exclusion Criteria
* Recent thoracic regional analgesia (\< 1 month)
* Preoperative dementia or other neurologic or psychiatric disease incompatible with VAS pain scoring.
* Other technique of regional anesthesia (e.g. thoracic epidural)
* Opposition to data collection
Secondary exlusion criteria:
* Postoperative prolonged sedation in ICU (\> 12 hours)
* Postoperative surgical complication requiring surgical revision during the first two days.
* Opposition to data collection expressed secondarily
18 Years
ALL
No
Sponsors
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University Hospital, Montpellier
OTHER
Responsible Party
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Principal Investigators
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Pierre Sentenac, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
UH MONTPELLIER
Locations
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Uh Montpellier
Montpellier, , France
Countries
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Other Identifiers
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RECHMPL19_0582
Identifier Type: -
Identifier Source: org_study_id
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