Efficacy and Tolerance of Therapeutic Apheresis in Paediatric Neurology: a French Multicenter Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-15

Study Completion Date

2021-12-31

Brief Summary

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After developing in pediatric hematology and nephrology, therapeutic apheresis is increasingly used in pediatric neurology despite a sparse level of evidence.

There are a few retrospective series with a small number of patients, concerning mainly autoimmune diseases (encephalitis, myasthenia gravis, polyradiculoneuritis).

The objective of this work is to study therapeutic apheresis (including plasma exchange and immunoadsorption) among french neuropediatric tertiary centers and to prove that this treatment modality is effective and well tolerated in pediatric neurology diseases.

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Detailed Description

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Multicenter medical data collection :

* Montpellier
* Toulouse
* Bordeaux
* Marseille
* Nancy
* Paris Kremlin Bicêtre
* Paris Robert Debré
* Paris Necker
* Paris Trousseau
* Lyon
* Besançon
* Rennes
* Reims
* Strasbourg
* La Réunion
* Nantes
* Tours

Conditions

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Apheresis Related Complication

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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plasma exchange

All patients underwent plasma exchanges between 2014 and 2019 for a neuropediatric pathology

Efficacy of apheresis

Intervention Type OTHER

Efficacy of apheresis

immunoadsorption

All patients who underwent immunoadsorptions between 2014 and 2019 for a neuropediatric pathology

Efficacy of apheresis

Intervention Type OTHER

Efficacy of apheresis

Interventions

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Efficacy of apheresis

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Children under 18.
* Supported in a participating CHU between 2014 and 2019.
* Having benefited from therapeutic apheresis (plasma exchanges and immunoadsorption) in a neuropediatric indication