Prevalence, Risk Factors and Outcomes of Pediatric Vascular Thrombosis

NCT ID: NCT05889897

Last Updated: 2023-07-18

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 15 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-08-01
• Study Completion Date: 2024-07-01

Brief Summary

This study is aimed to identify the prevalence, risk factors and outcomes of children with either venous or arterial thromboembolism admitted to children hospital Assiut University aiming at early detection and avoidance of catastrophic complications .

Detailed Description

Thrombosis is a blood clot that develops within veins or sometimes arteries in the body.

Occur most commonly in the inferior and superior vena cava, their major tributaries, the deep veins of the extremities, the splanchnic veins, as well as the cerebral venous sinuses.

The incidence of venous thromboembolism (VTE) increases with age. In the pediatric population (0-18 years) the incidence is approximately 0.7-2.1 cases per 100,000 children,1-3 while in the adult population the incidence is 100-150 per 100,000.4

Risk factors include the presence of central venous lines, trauma, major surgery followed by bedrest, immobilization, infection (cellulitis, osteomyelitis, phlebitis), cancer chemotherapy, inflammatory bowel disease, nephrotic syndrome, obesity, dehydration, and total parenteral nutrition.

Patients with vascular thromboembolism present with various symptoms depending on site of thrombosis , symptoms include swelling, redness, pain , low-grade fever In cases that develop pulmonary embolism they experience chest pain and shortness of breath that begin suddenly

Diagnosis of vascular thromboembolism include combination of signs and symptoms together with laboratory investigations that include routine lab investigations, D-dimer , protein s , protein C and antithrombin lll also imaging studies as Doppler US , MSCT with angiography and MRV

Vascular thrombosis mainly treated with anticoagulant therapy with subcutaneous injection of low molecular weight heparin These medications prevent the clot from growing and decrease the risk of its breaking apart and causing further complications Other treatments may include wearing compression stockings and applying warm packs to improve blood flow and pain caused by the clot

Conditions

Vascular Thrombosis

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Age : From 1day to 18 years.
• Sex : Both genders.
• Confirmed diagnosed cases, either Symptomatic or asymptomatic venous and arterial thromboembolism established by an imaging study.
• All patients admitted to the different units of children hospital including surgical unit.

Exclusion Criteria

• Age more than 18 years.
• Patient Known to have Sickle cell disease.

• Minimum Eligible Age: 1 Day
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Doaa Sayed Shaker Ahmed

principle investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Maher Mokhtar, Prof

Role: PRINCIPAL_INVESTIGATOR

Assiut University

Mervat Amin, Assist Prof

Role: PRINCIPAL_INVESTIGATOR

Assiut University

Central Contacts

Doaa sayed

Role: CONTACT

nananony551996@gmail.com

01064884771

Other Identifiers

pediatric vascular thrombosis

Identifier Type: -

Identifier Source: org_study_id