Optimized Volumetry in Radiology: Interest in Pediatric Brain MRI in the Exploration of Focal Epilepsy
NCT ID: NCT05100771
Last Updated: 2024-06-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
240 participants
OBSERVATIONAL
2022-03-14
2025-03-31
Brief Summary
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Detailed Description
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The prevalence of patients with non lesional epilepsy defined by MRI is significantly higher in children (31%) than in adults (21%). Epileptic patients with normal conventional MRI have a lower chance of having surgery than those with lesions demonstrated by presurgical MRI and, if so, less chance of becoming seizure-free. It can be challenging to depict brain volume abnormalities in the pediatric population on MRI. The major challenge is therefore to raise sensitivity of brain imaging analysis. Voxel-based morphometric MRI post-processing in MRI-negative epilepsies can be a practical and valuable tool to aid subtle MRI abnormalities detection and confirm visually identified questionable abnormalities in patients with focal epilepsy.
In this study, we prospectively included children with suspected focal epilepsy having a brain MRI using a MP2RAGE sequence and a post-processing morphometric analysis program (MAP) allowing us to obtain automatically both brain volumetry and T1 relaxometry. The MAP has been validated with reference ranges in healthy children. Our hypothesis was that the quantitative information will improve the sensitivity of brain MRI in children with suspected focal epilepsy. The objectives were to compare the rate of detection of a focal cerebral lesion on the brain MRI carried out during the exploration of suspected focal epilepsy without then with the quantitative volumetry and T1 relaxometry obtained in the inclusion center and then by double anonymized review.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Experimental group
The experimental group will be made up of patients with focal epilepsy
Pediatric brain MRI
Routine brain MRI with automated quantitative information (brain volumetry and T1 relaxometry)
Interventions
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Pediatric brain MRI
Routine brain MRI with automated quantitative information (brain volumetry and T1 relaxometry)
Eligibility Criteria
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Inclusion Criteria
* Referred or followed by a pediatrician for epilepsy with focal onset
* Requiring brain MRI as part of the work-up
Exclusion Criteria
* MRI not interpretable
* Clinical and epileptic data not available or not specifying focus
1 Year
18 Years
ALL
No
Sponsors
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University Hospital, Tours
OTHER
Responsible Party
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Principal Investigators
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Baptiste Morel
Role: PRINCIPAL_INVESTIGATOR
CHU Tours
Locations
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CHU Angers
Angers, , France
CHU Grenoble
Grenoble, , France
CHU Montpellier
Montpellier, , France
CHU Rennes
Rennes, , France
Hôpital Clocheville
Tours, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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DR210107
Identifier Type: -
Identifier Source: org_study_id
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